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Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Type of method:
column elution method

Test material

Constituent 1
Chemical structure
Reference substance name:
(3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
EC Number:
228-475-1
EC Name:
(3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
Cas Number:
6277-14-1
Molecular formula:
C32H48O5
IUPAC Name:
(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-acetyloxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Results and discussion

Water solubility
Key result
Water solubility:
ca. 23.73 g/L
Conc. based on:
test mat.
Incubation duration:
ca. 1.53 min
Remarks on result:
other: Mean of 4 results

Any other information on results incl. tables

 Injection name  Time  Conc  Volume x dilution  Conc. Saturated solution
   Min  µg/mL  mL  mg/mL
 Sample 1 dil 1:10 1.53   1.676  10  16.76
  Sample 2 dil 1:10  1.53   3.021  10  30.21
 Sample 3 dil 1:10 1.53   2.109  10  21.09
  Sample 4 dil 1:10  1.53   2.685  10  26.85
       

 Mean 23.73

       

  St. Deviation: 6.0; RSD(%) 25.2

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The waters solubility of Acetyl Glycyrrhetinic acid result 23.7 (slightly soluble).