Registration Dossier
Registration Dossier
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EC number: 228-475-1 | CAS number: 6277-14-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
Test material
- Reference substance name:
- (3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
- EC Number:
- 228-475-1
- EC Name:
- (3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
- Cas Number:
- 6277-14-1
- Molecular formula:
- C32H48O5
- IUPAC Name:
- (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-acetyloxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- ca. 23.73 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- ca. 1.53 min
- Remarks on result:
- other: Mean of 4 results
Any other information on results incl. tables
| Injection name | Time | Conc | Volume x dilution | Conc. Saturated solution |
| Min | µg/mL | mL | mg/mL | |
| Sample 1 dil 1:10 | 1.53 | 1.676 | 10 | 16.76 |
| Sample 2 dil 1:10 | 1.53 | 3.021 | 10 | 30.21 |
| Sample 3 dil 1:10 | 1.53 | 2.109 | 10 | 21.09 |
| Sample 4 dil 1:10 | 1.53 | 2.685 | 10 | 26.85 |
Mean 23.73 |
||||
St. Deviation: 6.0; RSD(%) 25.2 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The waters solubility of Acetyl Glycyrrhetinic acid result 23.7 (slightly soluble).
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