Registration Dossier
Registration Dossier
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EC number: 228-475-1 | CAS number: 6277-14-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Acetoxolone Tox Acute
- Author:
- Canadian Centre for Occupational health and Safety
- Year:
- 2 018
- Bibliographic source:
- RTECS number RK0177570
Materials and methods
Test guideline
- Guideline:
- other: Method not published
- Principles of method if other than guideline:
- Animals were treatment with the test material at different dosages and the mortality evaluated.
- GLP compliance:
- not specified
- Test type:
- other: not reported
Test material
- Reference substance name:
- (3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
- EC Number:
- 228-475-1
- EC Name:
- (3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
- Cas Number:
- 6277-14-1
- Molecular formula:
- C32H48O5
- IUPAC Name:
- (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-acetyloxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 300 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- Details of toxic effects not reported other than lethal dose value
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
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