Registration Dossier
Registration Dossier
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EC number: 204-024-4 | CAS number: 113-24-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolic and Histologic Effects of Sodium PyruvateTreatment in the Rat after Cortical Contusion Injury
- Author:
- Masamichi Fukushima, Stefan M. Lee, Nobuhiro Moro, David A. Hovda, and Richard L. Sutton
- Year:
- 2 009
- Bibliographic source:
- JOURNAL OF NEUROTRAUMA 26:1095–1110 (July 2009)ª Mary Ann Liebert, Inc.
DOI: 10.1089=neu.2008.0771
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The publication provides suffient details on the study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium pyruvate
- EC Number:
- 204-024-4
- EC Name:
- Sodium pyruvate
- Cas Number:
- 113-24-6
- Molecular formula:
- C3H4O3.Na
- IUPAC Name:
- sodium 2-oxopropanoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- he SP (P2256, Sigma, St. Louis, MO) was dissolved in sterile water (500 mg=mL, 4.5 M, pH 7.4) immediately prior to scheduled injections.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Type of coverage:
- other: intraperitoneal
- Vehicle:
- water
- Details on dermal exposure:
- Animals received an injection of sodium pyruvate (500 or 1000 mr/kg bw).
- Doses:
- 500 mg/kg bw
1000 mg/kg bw
3x 1000 mg/kg bw hourly - No. of animals per sex per dose:
- at least 5 per dose
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Mortality:
- not observed
Applicant's summary and conclusion
- Conclusions:
- Even with three hourly intraperitoneal injections of sodium pyruvate no deaths occured.
The uptake during dermal exposure with the same amount of substance would be lower. As a worst-case assumption it can be stated that the LC50, dermal is >= 3000 mg/kg bw.
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