Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Principles of method if other than guideline:
No guideline is required for QSAR.
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
41.05 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: A standard duration of 96 h for acute toxicity studies on fish can be assumed.
Conclusions:
QSAR model IRFMN predicts that sodium pyruvate is non-toxic for fish with a LC50 value of 41.05 mg/L based on 6 similar compounds.
Executive summary:

Prediction is 41.05 mg/L, the result appears reliable.


Reliability 3/3

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Principles of method if other than guideline:
No guideline is required for QSAR.
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
89.46 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: A standard duration of 96 h for acute toxicity studies on fish can be assumed.
Conclusions:
QSAR model NIC 1.0.0 predicts that sodium pyruvate is non-toxic for fish with a LC50 value of 89.46 mg/L based on 6 similar compounds.
Executive summary:

Prediction is 89.46 mg/L, the result appears reliable.


Reliability 3/3

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Principles of method if other than guideline:
No guideline is required for QSAR.
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
253 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: A standard duration of 96 h for acute toxicity studies on fish can be assumed.
Conclusions:
QSAR model IRFMN/Combase 1.0.0 predicts that sodium pyruvate is non-toxic for fish with a LC50 value of 253 mg/L based on 6 similar compounds.
Executive summary:

Prediction is 253 mg/L, but the result shows some critical aspects,which require to be checked: - some atom centered fragments of the compound have not beenfound in the compounds of the training set or are rare fragments (1infrequent fragments found)


Reliability 2/3

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Principles of method if other than guideline:
No guideline is required for QSAR.
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
161.38 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: A standard duration of 96 h for acute toxicity studies on fish can be assumed.
Conclusions:
QSAR model KNN predicts that sodium pyruvate is non-toxic for fish with a LC50 value of 161.38 mg/L based on 6 similar compounds.
Executive summary:

Prediction is 161.38 mg/L, but the result shows some critical aspects,which require to be checked: - some similar molecules found in the training set have experimentalvalues that disagree with the predicted value - the maximum error in prediction of similar molecules found in thetraining set has a moderate value, considering the experimental variability


Reliability 3/3

Description of key information

Based on the result of 5 QSAR models the lowest LC50 was 41.05 mg/L. Thus the LC50 fish for sodium pyruvate is expressed as >= 41.05 mg/L as a worst-case assumption.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
LC50
Effect concentration:
>= 41.05 mg/L

Additional information