4-[3-(1-naphthylamino)propyl]morpholine

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 4, 2016 to September 2, 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Principles of method if other than guideline:

Experimental Design:
Solubility of the test material at 250 mg/mL PG and approximately 5,000 μg/mL acetonitrile + 0.1% formic acid stored under ambient temperature, exposed to normal lighting conditions was assessed by visual inspection.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4-[3-(1-naphthylamino)propyl]morpholine

EC Number:

226-033-2

EC Name:

4-[3-(1-naphthylamino)propyl]morpholine

Cas Number:

5235-82-5

Molecular formula:

C17H22N2O

IUPAC Name:

N-[3-(morpholin-4-yl)propyl]naphthalen-1-amine

Test material form:

solid: granular

Details on test material:

Colour: Dark Brown to Black
GLP Characterized: January 21, 2016

Specific details on test material used for the study:

Test Material Name: 4-(3-(1-naphthylamino)propyl)morpholine
Chemical Name: N-1-Naphthalenyl-4-morpholinepropanamine
Synonyms: None
Lot/Reference/Batch Number: ZA01212016
Purity/Characterization (Method of Analysis and Reference): The purity of the test material was determined to be 94.4% by liquid chromatography with identification by nuclear magnetic resonance spectroscopy and liquid chromatography mass spectrometry (Ferrer, 2016a). Standards were not corrected for purity.
Test Material Stability Under Storage Conditions: 4-(3-(1-Naphthylamino)propyl)morpholine, lot ZA01212016, was determined to be stable for 2 weeks at 54°C which is equivalent to 24 months under ambient storage conditions as tested under USEPA OPPTS Guideline 830.6313 (Ferrer, 2016b).

Results and discussion

Solubility in organic solvents / fat solubility

Key result

Medium:

other: acetonitrile + 0.1% formic acid

Solubility:

5 000 other: μg/mL

Temp.:

23 °C

Remarks on result:

other: Solubility of 4-(3-(1-naphthylamino)propyl)morpholine (Lot # ZA01212016) has been demonstrated at a concentration of approximately 5,000 μg/mL in acetonitrile + 0.1% formic acid.

Test substance stable:

yes

Details on results:

Solubility was confirmed by visual inspection at a concentration of approximately 5000 μg/mL acetonitrile + 0.1% formic acid.

Applicant's summary and conclusion

Conclusions:

Solubility of 4-(3-(1-naphthylamino)propyl)morpholine (Lot # ZA01212016) has been demonstrated at a concentration of approximately 5,000 μg/mL in acetonitrile + 0.1% formic acid.

Executive summary:

Solubility of the test material at 250 mg/mL PG and approximately 5,000 μg/mL acetonitrile + 0.1% formic acid stored under ambient temperature, exposed to normal lighting conditions was assessed by visual inspection.

A solubility assessment was performed by dissolving approximately 0.1 g of 4-(3-(1-naphthylamino)propyl)morpholine (Lot # ZA01212016) in approximately 25 mL of acetonitrile + 0.1% formic acid. Solubility was confirmed by visual inspection at a concentration of approximately 5000 μg/mL acetonitrile + 0.1% formic acid.

Solubility of 4-(3-(1-naphthylamino)propyl)morpholine (Lot # ZA01212016) has been demonstrated at a concentration of approximately 5,000 μg/mL in acetonitrile + 0.1% formic acid.