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Diss Factsheets
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EC number: 201-969-4 | CAS number: 90-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- low test concentration
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
- Reference Type:
- publication
- Title:
- Assessment of the acute toxicity and potential irritancy of hair dye constituents
- Author:
- Lloyd G.K., Ligget M.P., Kynoch S.R. and Davies R.E.
- Year:
- 1 977
- Bibliographic source:
- Food and Chemical Toxicity, 15, 607- 610
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: procedure was based on the Consumer Product Safety Commission of the USA (Code of Federal Regulation, Title 16, Sec. 1500.41)
- Short description of test conditions: An solution of 2.5% solution of naphthol was evaluated in New Zealand White rabbits, this application was made to the intact and abraded skin
- Parameters analysed / observed: Primary Irritant Code - GLP compliance:
- no
Test material
- Reference substance name:
- 1-naphthol
- EC Number:
- 201-969-4
- EC Name:
- 1-naphthol
- Cas Number:
- 90-15-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- naphthalen-1-ol
- Test material form:
- solid
- Details on test material:
- No data
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: No data
- Expiration date of the lot/batch: No data
- Purity test date: No data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: No data
- Stability under test conditions: No data
- Solubility and stability of the test substance in the solvent/vehicle: No data
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No data
TREATMENT OF TEST MATERIAL PRIOR TO TESTING No
FORM AS APPLIED IN THE TEST: Suspension
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- other: Gum Tragacanth
- Remarks:
- Kipton Bros, London, Grade 1, BP
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): 2.5 % w/v
VEHICLE
- Amount(s) applied (volume or weight with unit): No data
- Concentration (if solution): 0.5%
- Lot/batch no. (if required): No data
- Purity: No data - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours (24 hours treatment and 48 hours observation)
- Number of animals:
- 3 (intact skin) and 3 (abraded skin)
- Details on study design:
- TEST SITE
- Area of exposure:
- % coverage: No data
- Type of wrap if used: surgical gauz and the entire trunk of the animal is wrapped with an impervious material such as rubberized cloth (to maintain the test patches and retards the evaporation)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: 24 hours
OBSERVATION TIME POINTS : 24 and 72 hours
SCORING SYSTEM: Primary irritation
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- One of the animals showed any observable response to treatment throughout the 72 hours observation period.
There was no other reaction observed at 24 hours or 72 hours later. - Other effects:
- - Other adverse local effects: No data
- Other adverse systemic effects: No data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Note: harmonized classification as Skin Irr 2
- Conclusions:
- Under the conditions of the experiment, a 2.5% aqueous suspension of 1-naphthol was considered not to be irritant to rabbit skin.
- Executive summary:
The skin irritation potential of 1-naphthol was evaluated in New Zealand White rabbits. Application of a 2.5% solution in aqueous gum tragacanth was made to the intact and abraded skin. The period of application was not stated. There was no reaction observed at 24 hours or 72 hours later.
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