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EC number: 201-969-4 | CAS number: 90-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Version / remarks:
- Not specified
- Principles of method if other than guideline:
- General description has several elements of scientific requirements for this type of study
- GLP compliance:
- not specified
- Test type:
- traditional method
Test material
- Reference substance name:
- 1-naphthol
- EC Number:
- 201-969-4
- EC Name:
- 1-naphthol
- Cas Number:
- 90-15-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- naphthalen-1-ol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Test item is identified with the CAS number from the information given in the IUCLID2003 Dataset.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Details on inhalation exposure:
- Two types of doses / exposures are mentioned. One under the L0 determination (Saturated atmosphere of chemical vapor), and another under the LC50 determination (Saturated atmosphere of mist, vapor and decomposition products) as described under the study design
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- Not specified
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
- Details on study design:
- Exposure type: Saturated atmosphere of chemical vapor:
Substantially saturated vapor was prepared by spreading 50-100 grams of 1-naphthol over a 200 cm2 area on a shallow tray placed near the top of a 120 liter plexiglas chamber which is then sealed for at least 16 hours while an intermittently operated fan agitates the internal chamber atmosphere. Rats were then introduced into a gasketed drawer-type cage designed and operated to minimize vapor loss. Animals were exposed for six (6) hours and observed for mortality and toxicity for 14 days.
Exposure type: Saturated atmosphere of mist, vapor and decomposition products:
1-naphthol was heated to 179 degree C. Air was passed over the heated sample and mist, vapor, and any oxidation products generated were delivered to rats in a 9 liter glass exposure chamber. Animals were exposed for six (6) hours. Animals were observed for mortality and toxicity for 14 days.
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC0
- Exp. duration:
- 6 h
- Remarks on result:
- not determinable
- Remarks:
- No mortality or signs of toxicity in rats exposed to a saturated vapor atmosphere.
- Sex:
- not specified
- Dose descriptor:
- LC50
- Exp. duration:
- 6 h
- Remarks on result:
- not determinable
- Remarks:
- No mortality when rats exposed to s saturated vapor atmosphere of heated 1-naphthol. Signs of toxicity included eye irritation and hypoactivity
- Mortality:
- None
- Clinical signs:
- other: Signs of toxicity included eye irritation and hypoactivity when rats were exposed for 6 hours to a saturated vapor atmosphere of heated 1-naphthol.
- Body weight:
- Not described
- Gross pathology:
- Not described
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- STOT SE Cat 3 (Note, this is also a harmonized classification)
- Conclusions:
- LC50 not determinable as the concentrations were not provided. However, STOT SE Cat 3 was assigned per UN GHS due to the eye irritation and hypoactivity from exposure to heated saturated vapor. No mortality reported.
- Executive summary:
Rats were exposed for 6 hours with saturated atmosphere of 1 -naphthol or a saturated atmosphere of mist, vapor, and decomposition products of heated (179 degrees C) 1 -naphthol. The LC50 was not reported and the exposure concentrations were not provided. No deaths occured. The results cannot be used for Acute Toxicity - inhalation classification. However, STOT SE Cat 3 was assigned per UN GHS due to the hypoactivity from exposure to heated saturated vapor of 1 -naphthol.
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