1,1'-(4-chlorobutylidene)bis[4-fluorobenzene]

Endpoint summary

Description of key information

Biodegradation in water:

Biodegradability of test chemical is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The test chemical 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene (CAS no.3312 -04 -7) showed 0.20 % biodegradation in 28 days by BOD parameter and microorganisms as inoculum. This percent biodegradation value is very less so it is concluded that this test chemical is not readily biodegradable.

Biodegradation in water and Sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene (CAS No. 3312 -04 -7). If released in to the environment, 1.56 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene in water is estimated to be 180 days (4320 hrs). The half-life (180 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene in sediment is estimated to be 1620.833 days (38900 hrs). Based on this half-life value, it indicates that the chemical 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene is persistent in sediment as well.

Biodegradation in soil:

The half-life period of1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene(CAS No.3312 -04 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 62.5% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzenein soil is estimated to be 360 days ( 8640 hrs). Based on this half-life value of1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene, it is concluded that the chemical is persistent in the soil environment and the exposure risk to soil dwelling animals is high.

Additional information

Biodegradation in water:

Predicted data for target compound1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene (CAS no.3312 -04 -7) and supporting weight of evidence studies for its closest read across chemicals with log Kow as a primary descriptor were reviewed for the biodegradation endpoint which are summarized as below.

Biodegradability of test chemical is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The test chemical 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene (CAS no.3312 -04 -7) showed 0.20 % biodegradation in 28 days by BOD parameter and microorganisms as inoculum. This percent biodegradation value is very less so it is concluded that this test chemical is not readily biodegradable.

 

 In another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) BIOWIN v4.10. The biodegradation potential of the test chemical   1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene (CAS no. 3312 -04 -7) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzeneis expected to be not readily biodegradable.

 

 In the supporting weight of evidence study from authoritative database ( j check 2017). The read across chemical 6-chloro-2-N-ethyl-4-N-(propan-2-yl)-1,3,5-triazine-2,4-diamine ( 1912-24-9) was subjected to biodegradation test by taking activated sludge as a inoculums at 30 mg/L concentration . Biodegradation was analysed by using two parameters BOD and HPLC. The initial concentration of test chemical was 100 mg/L and study design is of standard type. After 4 weeks( 28 days) chemical 6-chloro-2-N-ethyl-4-N-(propan-2-yl)-1,3,5-triazine-2,4-diamine showed 1% biodegradation by BOD and HPLC parameters. So it is concluded that the read across chemical 6-chloro-2-N-ethyl-4-N-(propan-2-yl)-1,3,5-triazine-2,4-diamine is not readily biodegradable.

 

In another supporting weight of evidence study from same source as stated above biodegradation experiment was carried out for read across chemical (chlorodiphenylmethyl)benzene ( CAS no. 76-83-5) by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using BOD and HPLC parameter. The initial concentration of test chemical was 100 mg/L and study design is of standard type. After 4 weeks (28 days) test chemical showed 0% biodegradation by BOD and HPLC. So it is concluded that read across chemical (chlorodiphenylmethyl)benzene is not readily biodegradable.

 

All the studies stated above showed same results i.e., test chemical is not readily biodegradable. Therefore on the basis of above results for target chemical1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene (CAS no.3312 -04 -7) from ( EPI suite 2017 and OECD QSAR tool box v3.3 2017) and for its read across substances ( from authoritative database) it is concluded that the target chemical1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene is be expected to be not readily biodegradable.

Biodegradation in water and Sediments:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene (CAS No. 3312 -04 -7). If released in to the environment, 1.56 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene in water is estimated to be 180 days (4320 hrs). The half-life (180 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene in sediment is estimated to be 1620.833 days (38900 hrs). Based on this half-life value, it indicates that the chemical 1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene is persistent in sediment as well.

Biodegradation in soil:

The half-life period of1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene(CAS No.3312 -04 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 62.5% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzenein soil is estimated to be 360 days ( 8640 hrs). Based on this half-life value of1-[4-chloro-1-(4-fluorophenyl)butyl]-4-fluorobenzene, it is concluded that the chemical is persistent in the soil environment and the exposure risk to soil dwelling animals is high.