Registration Dossier
Registration Dossier
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EC number: 221-998-6 | CAS number: 3312-04-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Evaluation of health hazards by exposure to Chlorinated paraffins and proposal of a health-based quality criterion for ambient air
- Author:
- The Danish Environmental Protection Agency
- Year:
- 2 013
- Bibliographic source:
- The Danish Environmental Protection Agency, 2013
- Reference Type:
- secondary source
- Title:
- Risk assessment of alkanes, c14-17, chloro (medium-chained chlorinated paraffins) CAS no. 85535-85-9
- Author:
- European Chemicals Agency (ECHA)
- Year:
- 2 008
- Bibliographic source:
- Risk assessment of alkanes, c14-17, chloro (medium-chained chlorinated paraffins),2008
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mention below
- Principles of method if other than guideline:
- Acute oral toxicity study of Alkanes C14-17, chloro was performed in Rat
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Alkanes, C14-17, chloro
- EC Number:
- 287-477-0
- EC Name:
- Alkanes, C14-17, chloro
- Cas Number:
- 85535-85-9
- IUPAC Name:
- Alkanes C14-17, chloro
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Alkanes C14-17, chloro
- Molecular formula : No data available
- Molecular weight : No data available
- Substance type: organic
- Physical state: liquid
- Purity: No data available
- Impurities (identity and concentrations): No data available
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Alkanes C14-17, chloro
- Molecular formula : No data available
- Molecular weight : No data available
- Substance type: organic
- Physical state: liquid
- Purity: No data available
- Impurities (identity and concentrations): No data available
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 15000mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed
- Clinical signs:
- other: signs of toxicity included urinary incontinence or “oily/moist pelt around the anal-genital region” were observed
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be >15000mg/kg body weight. When rats were treated with Alkanes C14-17, chloro (85535-85-9) orally.
- Executive summary:
Acute oral toxicity study was done in rat using Alkanes C14-17, chloro(85535-85-9).No mortality observed in treated rat at dose 15000mg/kg .Clinical signs like urinary incontinence or “oily/moist pelt around the anal-genital region ”were observed in treated rats. HenceLD50 was considered to be>15000mg/kgbody weight. When rats were treated with Alkanes C14-17, chloro (85535-85-9) orally.
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