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EC number: 813-604-1
CAS number: 68533-01-7
The test substance NM01 was tested for its mutagenic potential based on
the ability to induce point mutations in selected loci of several
strains of Salmonella typhimurium and Escherichia coli (TA 1535, TA 100,
TA 1537, TA 98 and E. coli WP2 uvrA), in a reverse mutation assay. A
standard plate test and a preincubation test were conducted, both with
and without metabolic activation (liver S9 mix from induced rats), and
both covering a dose range of 33 μg - 5 000 μg/plate. No precipitation
of the test substance was found with and without S9 mix. A weak
bacteriotoxic effect was occasionally observed depending on the strain
and test conditions at 5 000 μg/plate. A biologically relevant increase
in the number of his+ or trp+ revertants was not observed in the
standard plate test or in the preincubation test either without S9 mix
or after the addition of a metabolizing system.
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