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EC number: 813-604-1
CAS number: 68533-01-7
In an acute oral toxicity study according to the Acute Toxic Class
method, clinical signs were observed in the in female rats receiving
2000 mg/kg bw (impaired general state and piloerection in all animals),
but not in the second group receiving 300 mg/kg. No mortality occurred
in any of the dose groups. There were no macroscopic pathological
findings in all animals sacrificed at the end of the observation period.
In an acute oral toxicity study performed according to the Acute Toxic
Class method, doses of 2000 and 300 mg/kg bw of the test item NM01
(preparations in 0.5% CMC-solution) were administered by gavage to three
test groups of three fasted Wistar rats each (2000 mg/kg bw in 6
females, 300 mg/kg bw in 3 females). Clinical signs were observed in the
first test group receiving 2000 mg/kg bw only (impaired general state
and piloerection in all animals). No mortality occurred in any of the
dose groups. There were no macroscopic pathological findings in all
animals sacrificed at the end of the observation period. The mean body
weight of the surviving animals increased within the normal range
throughout the study period with one exception in the 300 mg/kg bw test
group. One animal showed stagnation of body weight in the second week,
which was, however, considered an unspecific effect.
As the oral LD50 in rats was found to be >2000 mg/kg, the classification
criteria of the CLP regulation are not met.
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