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EC number: 218-737-3 | CAS number: 2222-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Studies on 5,12-dihydro-quino<2,3-b>acridine-7,14-dione with Attachments
- Author:
- Environmental Protection Agency, Washington, DC. Office of Toxic
- Year:
- 1 991
- Bibliographic source:
- Office of Toxic Substances, EPA/OTS; Doc #86-920000391S, NTIS/OTS0533729, 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Test for skin sensitization potential have been conducted on 5, 12-dihydroquino[2,3-b]acridine-7,14-dione.
- GLP compliance:
- not specified
- Type of study:
- other: No data available.
- Justification for non-LLNA method:
- Not specified.
Test material
- Reference substance name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- EC Number:
- 213-879-2
- EC Name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Cas Number:
- 1047-16-1
- Molecular formula:
- C20H12N2O2
- IUPAC Name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): quinacridone (5, 12-dihydroquino[2,3-b]acridine-7,14-dione)
- Molecular formula: C20H12N2O2
- Molecular weight: 312.322 g/mol
- Substance type: Organic
- Physical state: Solid
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: albino
- Sex:
- male
- Details on test animals and environmental conditions:
- No data available.
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- other: Water containing 1% Duponol PT
- Concentration / amount:
- 10%
Challenge
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- other: Water containing 1% Duponol PT
- Concentration / amount:
- 10%
- No. of animals per dose:
- 10 animals.
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: No data
- Exposure period: no data
- Test groups: yes
- Control group: No data
- Site: intact skin
- Frequency of applications: No data
- Duration: No data
- Concentrations: 10%
B. CHALLENGE EXPOSURE
- No. of exposures: 9
- Day(s) of challenge: 14 days
- Exposure period: 14 days
- Test groups: yes
- Control group: No data
- Site: abraded skin
- Concentrations: 10%
- Evaluation (hr after challenge): 336 hour - Challenge controls:
- No data available
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 336
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- Produced mild irritation, but showed no sensitization reaction.
- Remarks on result:
- no indication of skin sensitisation
In vivo (LLNA)
- Cellular proliferation data / Observations:
- CLINICAL OBSERVATIONS:Produced mild irritation, but showed no sensitization reaction.
Any other information on results incl. tables
No indication of skin sensitization.
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione at a 10% concentration in aqueous suspension was a mild irritant at both intact and abraded skin of albino guinea pigs. However, the 5,12-dihydroquino[2,3-b]acridine-7,14-dione assessed not to be a skin sensitizer in the test with guinea pigs.
- Executive summary:
Tests for skin sensitization potential have been conducted for 5, 12-dihydroquino[2,3-b]acridine-7,14-dione (1047-16-1) on albino guinea pigs.When a 10% suspension of the material in water containing 1% of Duponol PT was applied to intact skin of 10 male albino guinea pigs, it produced mild irritation on five animals and none on the others. Applications of the same concentration to abraded skin were slightly more irritating.Challenge tests, following nine exposures of the 10% suspension to abraded skin and 2 weeks rest period, showed no sensitization potential. Therefore 5, 12-dihydroquino[2,3-b]acridine-7,14-dione (1047-16-1) was considered to be non sensitizer in albino guinea pigs.
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