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EC number: 218-737-3 | CAS number: 2222-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from J-CHECK authoritative database
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Principles of method if other than guideline:
- Short term toxicity to green algae study was carried out for 72 hrs.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1H-dibenzo[a,d][7]annulen-1-one
- Molecular formula (if other than submission substance): C15H10O
- Molecular weight (if other than submission substance): 206.243 g/mol
- Smiles notation (if other than submission substance): c12c(ccc3c(c1=O)cccc3)cccc2
- InChI: 1S/C15H10O/c16-15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)15/h1-10H
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: green algae
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 72 h
- Nominal and measured concentrations:
- Nominal concentrations
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.011 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.09 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: AUG
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.022 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: AUG
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Short term toxicity to green algae study was carried out for 72 hrs. according to OECD Guideline 201 (Alga, Growth Inhibition Test) for chemical 1H-dibenzo[a,d][7]annulen-1-one. The 72 hr EC50 and NOEC value was determined to be 0.14 and 0.011 mg/l, respectively based on effect on growth rate of the test organism green algae, and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.09 and 0.022 mg/l, respectively.
- Executive summary:
Short term toxicity to green algae study was carried out for 72 hrs. The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the test compound 1H-dibenzo[a,d][7]annulen-1-one on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be 0.14 and 0.011 mg/l, respectively and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.09 and 0.022 mg/l, respectively. Thus, based on the EC50 value, it can be concluded that the substance 1H-dibenzo[a,d][7]annulen-1-one can be considered as toxic to aquatic organisms and thus can be classified as aquatic acute category 1 as per the CLP classification criteria.
Reference
Description of key information
Short term toxicity to green algae study was carried out for 72 hrs (J-CHECK, 2016). The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the test compound 1H-dibenzo[a,d][7]annulen-1-one on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be 0.14 and 0.011 mg/l, respectively and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.09 and 0.022 mg/l, respectively. Thus, based on the EC50 value, it can be concluded that the substance 1H-dibenzo[a,d][7]annulen-1-one can be considered as toxic to aquatic organisms and thus can be classified as aquatic acute category 1 as per the CLP classification criteria.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.14 mg/L
- EC10 or NOEC for freshwater algae:
- 0.011 mg/L
Additional information
1 experimental key studyfor the target chemical1H-dibenzo[a,d][7]annulen-1-one (CAS no. 2222-33-5) which are supported further by total 2 studies (from authoritative database) for its closest structurally similar read across substance with logKow as the primary descriptor were reviewed for the toxicity to aquatic algae and cyanobacteria end point which are summarized as below:
In a key study fromauthoritative database(J-CHECK, 2016) for target chemical1H-dibenzo[a,d][7]annulen-1-one (CAS no. 2222-33-5), short term toxicity to green algae study was carried out for 72 hrs. The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the test compound 1H-dibenzo[a,d][7]annulen-1-one on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be 0.14 and 0.011 mg/l, respectively and on the basis of AUG, the 72 hr EC50 and NOEC value was determined to be 0.09 and 0.022 mg/l, respectively.
In a supporting data for read across compound Anthraquinone (CAS no. 84 -65 -1) fromauthoritative database(J-CHECK, 2016), short term toxicity to green algae study was carried out for 72 hrs. The study was based on the effects of the read across compound Anthraquinone on green algae in a static fresh water system. Based on effect on growth rate of the test organism green algae, the 72 hr EC50 and NOEC value was determined to be > 0.035 and 0.035 mg/l, respectively and on the basis of areas under the growth curves, the 72 hr EC50 and NOEC value was determined to be > 0.4 mg/l, respectively.
Additional supporting study for toxicity to aquatic algae and cyanobacteria for read across chemicalAnthraquinone (CAS no. 84 -65 -1)was carried out for 90 mins (ECOTOX database, 2016). The study was based on the effects of the read across compound Anthraquinone on green algae in a static fresh water system. Based on effect on physiology of the test organism algae, the EC50 value was determined to be 0.684 mg/l, respectively.
Based on the overall reported results for target chemical 1H-dibenzo[a,d][7]annulen-1-one (from authoritative database J-CHECK, 2016) and for its read across substance (from J-CHECK and ECOTOX authoritative database), it can be concluded that the test substance 1H-dibenzo[a,d][7]annulen-1-one can be considered as toxic to aquatic organisms and thus can be classified as aquatic acute category 1 as per the CLP classification criteria.
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