Registration Dossier
Registration Dossier
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EC number: 211-448-3 | CAS number: 645-62-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 50 µl applied, instead of 100 µl
- Principles of method if other than guideline:
- Eye irritation was tested using an internal method (BASF-test)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhex-2-enal
- EC Number:
- 211-448-3
- EC Name:
- 2-ethylhex-2-enal
- Cas Number:
- 645-62-5
- Molecular formula:
- C8H14O
- IUPAC Name:
- 2-ethylhex-2-enal
- Details on test material:
- - Name of test material (as cited in study report): 2-Ethyl-hexen-2-al-1
- Physical state: liquid
- Analytical purity: ca 97 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: one drop of NaCl into the other eye
- Amount / concentration applied:
- ca 0.05 ml
- Duration of treatment / exposure:
- Treatment was once
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
Descriptive scores of the raw data have been converted to Draize numerical scores.
Animal |
Reading |
Opacity |
Iritis |
Redness |
Chemosis |
Comment |
1 |
1 h |
0 |
0 |
2 |
1 |
|
2 |
1 h |
0 |
0 |
2 |
1 |
|
1 |
24 h |
0 |
0 |
1 |
0 |
|
2 |
24 h |
0 |
0 |
1 |
0 |
|
1 |
48 h |
0 |
0 |
1 |
0 |
|
2 |
48 h |
0 |
0 |
1 |
0 |
|
1 |
72 h |
0 |
0 |
1 |
0 |
|
2 |
72 h |
0 |
0 |
1 |
0 |
|
1 |
8 d |
0 |
0 |
0 |
0 |
|
2 |
8 d |
0 |
0 |
0 |
0 |
|
mean |
24 - 72 h |
0 |
0 |
1.0 |
0 |
|
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
