Registration Dossier
Registration Dossier
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EC number: 211-448-3 | CAS number: 645-62-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD Guideline 401 with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhex-2-enal
- EC Number:
- 211-448-3
- EC Name:
- 2-ethylhex-2-enal
- Cas Number:
- 645-62-5
- Molecular formula:
- C8H14O
- IUPAC Name:
- 2-ethylhex-2-enal
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 2-Hexenal, 2-ethyl
- Impurities: Butyraldehyd
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 140 - 216 g; female: 118 - 174 g
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 5440, 4250, 3400, 2720, 1360, 170 mg/kg
- No. of animals per sex per dose:
- 10 males and 10 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: 1h after application; daily observations
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs; body weight was determined before the start of the study only
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 4 675 mg/kg bw
- Mortality:
- see: remarks on results
- Clinical signs:
- other: Dyspnea, abdominal position, lateral position, stagger
- Gross pathology:
- Sacrified animals: no macroscopic pathologic abnormalities were noted
Animals that died: atonic gastro-intestinal tract
Any other information on results incl. tables
Mortality:
| Dose in mg/kg bw | concentration % | 1 hour | 24 hours | 48 hours | 7 days |
| 5440 | 30 | 0/20 | 9/20 | 9/20 | 9/20 |
| 4250 | 30 | 0/20 | 12/20 | 12/20 | 12/20 |
| 3400 | 30 | 0/20 | 4/20 | 4/20 | 4/20 |
| 2720 | 30 | 0/20 | 0/20 | 0/20 | 0/20 |
| 1360 | 20 | 0/20 | 0/20 | 0/20 | 0/20 |
| 170 | 2 | 0/20 | 0/20 | 0/20 | 0/20 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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