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EC number: 215-089-3
CAS number: 1300-71-6
The eye irritancy of 3,5 xylenol was studies
in 6 New Zealand white rabbits using the method of the US consumer
product safety commission (code of Federal Regulations, Title 16 Section
1500.42). The animals were given a single instillation of 100mg into the
conjunctival sac of one eye and the effects were assessed at 24, 48 and
72 hrs after instillation. The effects were evaluated using the Draize
scoring system in accordance with the recommendations of ETAD. In all
rabbits, irritation of the conjunctivae with reddening, chemosis and
ocular dishcarge were present at all time points as was corneal
clouding, the effects being only slightly reversible during the 3 -day
observation period. The iris showed injected vessels. The average
irritation index was 58.4 and the substanvce was evaluated as severely
irritating in accordance with the recommednations of ETAD.
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