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EC number: 215-089-3
CAS number: 1300-71-6
Of the two
studies available on xylenols, 3,5 xylenol returned an equivocal result.
Whilst the author of this study concluded that the test material, 3,5
xylenol did not exhibit any skin sensitising potential, due to similar
skin reactions being elicited by the solvent and the test preparation,
the outcome of the study could not be concluded with confidence. The
study conducted on 2,4 xyelnol returned a positve result, furthermore,
no reactivity with the solvent was observed.
Draize test and the human maximisation test on p-cresol confirmed this
cresol isomer to be a non-sensitiser. The GPMT on o-cresol did not
provide sufficient information to allow a definitive conclusion to be
skin sensitisation data is available for ethyl phenols; based on
structural similarities a conservative approach who be to conclude that
ethyl phenols will give a similar effect to that observed by 2,4
xylenol, Skin Sensitiser.
conclusion for this endpoint who be that of a potential skin sensitiser.
Currently no validated in vivo methods are
available. Neither xylenols, cresols or ethylphenols contain reactive
chemical groups which are known respiratory sensitisers. Consequently
there is no concern regarding this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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