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EC number: 215-089-3
CAS number: 1300-71-6
Of the two
studies available on xylenols, 3,5 xylenol returned an equivocal result.
Whilst the author of this study concluded that the test material, 3,5
xylenol did not exhibit any skin sensitising potential, due to similar
skin reactions being elicited by the solvent and the test preparation,
the outcome of the study could not be concluded with confidence. The
study conducted on 2,4 xyelnol returned a positve result, furthermore,
no reactivity with the solvent was observed.
Draize test and the human maximisation test on p-cresol confirmed this
cresol isomer to be a non-sensitiser. The GPMT on o-cresol did not
provide sufficient information to allow a definitive conclusion to be
skin sensitisation data is available for ethyl phenols; based on
structural similarities a conservative approach who be to conclude that
ethyl phenols will give a similar effect to that observed by 2,4
xylenol, Skin Sensitiser.
conclusion for this endpoint who be that of a potential skin sensitiser.
Currently no validated in vivo methods are
available. Neither xylenols, cresols or ethylphenols contain reactive
chemical groups which are known respiratory sensitisers. Consequently
there is no concern regarding this endpoint.
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