Registration Dossier
Registration Dossier
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EC number: 201-143-3 | CAS number: 78-79-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Lethality study only; insufficient experimental detail to assess quality.
Data source
Reference
- Reference Type:
- publication
- Title:
- Response of lymphoid tissue to single and multiple inhalation exposures to isoprene and some relevant integral indices
- Author:
- Mamedov A
- Year:
- 1 979
- Bibliographic source:
- Gigiena Truda I Professional'Nye Zabolevaniya, Vol. 6, pp. 34-37
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Isoprene
- EC Number:
- 201-143-3
- EC Name:
- Isoprene
- Cas Number:
- 78-79-5
- Molecular formula:
- C5H8
- IUPAC Name:
- 2-methylbuta-1,3-diene
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- inhalation
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- 214 000 mg/m³ air
- Exp. duration:
- 4 h
- Clinical signs:
- other:
Applicant's summary and conclusion
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