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EC number: 930-690-7
CAS number: -
Five male and five female HanRcc:WIST (SPF) rats were treated with Shale
oil at 2000 mg/kg by dermal application in accordance with OECD 402 and
to GLP standard. The test item was applied undiluted as delivered from
the sponsor at a volume dosage of 2.04 mL/kg. The application period was
No mortality, clinical signs or abnormal body weight changes were
observed. Mild to moderate skin irritation effects were observed in all
The median lethal dose of Shale oil after single dermal administration
to rats of both sexes, observed over a period of 14 days is:
LD50 (rat): greater than 2000 mg/kg body weight.
Based on the rationale for read-across, it is considered acceptable to
use this study to address the same endpoint for heavy fraction of shale
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