Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 269-929-9 | CAS number: 68391-11-7 The complex combination of polyalkylated pyridines derived from coal tar distillation or as high-boiling distillates approximately above 150°C (302°F) from the reaction of ammonia with acetaldehyde, formaldehyde or paraformaldehyde.
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
- Migrated from Short description of key information:
Determination of acute inhalation toxicity was carried out with 5-ethyl-2-methylpyridine (MEP, CAS no.: 104-90-5, EC no.: 203-250-0). The read-across between the UVCB substance and the model constituent is justified.
A study according to EU Method B.42, OECD Guideline 429 and EPA OPPTS 870.2600 (Skin Sensitisation: Local Lymph Node Assay) was carried out. Tested at concentrations of 50 %, 37.5 %, 25 %, 10 % and 5 % as homogenous formulations (solutions) in a suitable vehicle (AOO) the test item was shown to shown to have sensitization potential (sensitizer). The calculated EC3-value in this LLNA was 22.4 % based on linear interpolation and 18.1 % based on regression curve analysis. Based on the EC3 values calculated using dose-response and regression curve analysis the test item was considered a weak sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
There is no data available on respiratory sensitisation. However, there is no indication for respiratory irritation from handling and use.
Justification for classification or non-classification
Based on the data available the substance is classified and labeled according to Regulation 1272/2008/EEC (CLP) as Skin sensitiser category 1, H317 May cause an allergic skin reaction and according to Directive 67/548/EEC (DSD) as Irritant Xi, R43 May cause sensitisation by skin contact.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
