Registration Dossier
Registration Dossier
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EC number: 269-929-9 | CAS number: 68391-11-7 The complex combination of polyalkylated pyridines derived from coal tar distillation or as high-boiling distillates approximately above 150°C (302°F) from the reaction of ammonia with acetaldehyde, formaldehyde or paraformaldehyde.
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Read-across from supporting substance Substance: 5-ethyl-2-methylpyridine (MEP) CAS no.: 104-90-5 EC no.: 203-250-0 Pyridine, alkyl derivatives is a substance of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCB, subtype 2). The substance is not a discrete chemical, but characterized by a variety of structures. The substance 2-ethyl-4-methylpyridine (CAS no. 26091-11-2) and its isomer 5-ethyl-2-methylpyridine (MEP, CAS no. 104-90-5) were selected as representative model structures. The read-across is based on the hypothesis that source and target substance have similar properties, because they share a common functional group, common precursors and the likelihood of common breakdown products via physical and biological processes, which result in structurally similar chemicals. Please see the attached read-across justification for details.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material: 5-ethyl-2-methyl-pyridine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 2.67 mg/L air
- Exp. duration:
- 4 h
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute inhalation toxicity study with rats a 4 h LC50 of 2.67 mg/L was determined.
- Executive summary:
Determination of acute inhalation toxicity was carried out with 5-ethyl-2-methylpyridine (MEP, CAS no.: 104-90-5, EC no.: 203-250-0). The read-across between the UVCB substance and the model constituent is justified. A study similar or equivalent to EU Method B.2 and OECD Guideline 403 (Acute Inhalation Toxicity) was carried out. Rats were dosed for 4 hours. An LC50 of 2.67 mg/L was obtained.
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