Registration Dossier
Registration Dossier
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EC number: 435-190-8 | CAS number: 246871-16-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral administration of FAT 41’029/A to Wistar rats at doses of 50, 200 and 1000 mg/kg/day, for 28 days resulted in no deaths, no test article-related clinical signs (following daily and weekly observation), no effects upon the parameters of the functional observation battery (including grip strength), no changes in body weight and food consumption, and no effects upon hematology or clinical biochemistry parameters, or organ weights. No test article-related macroscopic or microscopic changes were evident at necropsy.
Test article-related changes included slightly decreased locomotor activity at 1000 mg/kg/day, only.
Based on the results of this study, 200 mg/kg body weight/day was established as the no-observed-effect-level (NOEL) and 1000 mg/kg body weight/day as the no-observed-adverse-effect-level (NOAEL).
Justification for classification or non-classification
The test substance shall not be classified in accordance with CLP (Regulation EC No.1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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