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EC number: 232-077-3
CAS number: 7785-26-4
an acute dermal toxicity study performed according to OECD Guideline 402
and in compliance with GLP, a group of Sprague Dawley rats (5/sex/dose)
was given a single dermal application of alpha-pinene multiconstituent
at 2000 mg/kg bw. The test item was applied on dorsal area of the trunk
representing approximately 10% of the total body surface area of the
animals. The test site was then covered by a semi-occlusive dressing for
24 h. Animals were then observed for mortality, clinical signs and
bodyweights for 14 days and were all sacrificed for macroscopic
No mortality occurred during the
study. No systemic clinical signs related to the administration of the
test item were observed. Cutaneous reactions (erythema and dryness) were
noted in all animals (10/10) at 24-hour post-dose and were totally
reversible on day 13. Body weight gain of the animals remained normal
throughout the study. The macroscopic examination of the animals at the
end of the study did not reveal any treatment-related changes.
In conclusion, the LD50 of
test item alpha-pinene multiconstituent is higher than 2000 mg/kg body
weight by dermal route in the rat. Test item alpha-pinene
not have to be classified in accordance with
Regulation EC No. 1272/2008 on classification, labelling and packaging
of substances and mixtures and UN GHS.
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