Registration Dossier
Registration Dossier
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EC number: 203-870-1 | CAS number: 111-44-4
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: information from assessment report
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Bis(2-chloroethyl)ether, BUA Report 21 (December 1987)
- Author:
- BUA
- Year:
- 1 987
- Bibliographic source:
- Beratergremium für Umweltrelevante Altstoffe (BUA)ISBN 3-527-28515-6 (VCH, Weinheim)
Materials and methods
- Principles of method if other than guideline:
- no information
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-chloroethyl) ether
- EC Number:
- 203-870-1
- EC Name:
- Bis(2-chloroethyl) ether
- Cas Number:
- 111-44-4
- Molecular formula:
- C4H8Cl2O
- IUPAC Name:
- 1-chloro-2-(2-chloroethoxy)ethane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 7 hours daily 5 days per week
Results and discussion
Results of examinations
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- 420 mg/m3 in male rats
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 420 mg/m³ air
- Based on:
- not specified
- Sex:
- male
- Basis for effect level:
- body weight and weight gain
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The BUA assessment report has following statement:
"Within a period of 130 days, an air concentration of 420 mg/m³, inhaled by rats and guinea pigs 7 hours daily, 5 days per week, led to delayed weight gain of the male animals as opposed to the untreated control animals."
Applicant's summary and conclusion
- Executive summary:
The BUA assessment report has following statement:
"Within a period of 130 days, an air concentration of 420 mg/m³, inhaled by rats and guinea pigs 7 hours daily, 5 days per week, led to delayed weight gain of the male animals as opposed to the untreated control animals."
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