Registration Dossier
Registration Dossier
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EC number: 203-870-1 | CAS number: 111-44-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from handbook, no study details were provided.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Registry of Toxic Effects of Chemical Substances 1981 - 82, Volume 2, D-O
- Author:
- U.S. Department of Health and Human Services
- Year:
- 1 981
- Bibliographic source:
- NIOSH National Institute for Occupational Safety and Health
- Reference Type:
- other: internet data base
- Title:
- GESTIS Substance database
- Author:
- German Social Accident Insurance
- Year:
- 2 012
- Bibliographic source:
- http://www.dguv.de/ifa/en/gestis/stoffdb/index.jsp
- Reference Type:
- review article or handbook
- Title:
- Bis(2-chloroethyl)ether, BUA Report 21 (December 1987)
- Author:
- BUA
- Year:
- 1 987
- Bibliographic source:
- Beratergremium für Umweltrelevante Altstoffe (BUA)ISBN 3-527-28515-6 (VCH, Weinheim)
Materials and methods
- Principles of method if other than guideline:
- no information provided
- GLP compliance:
- not specified
- Test type:
- other: no information provided
Test material
- Reference substance name:
- Bis(2-chloroethyl) ether
- EC Number:
- 203-870-1
- EC Name:
- Bis(2-chloroethyl) ether
- Cas Number:
- 111-44-4
- Molecular formula:
- C4H8Cl2O
- IUPAC Name:
- 1-chloro-2-(2-chloroethoxy)ethane
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 75 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- oral rat LD50: 75 mg/kg bw
- Executive summary:
The handbook and database provide an oral rat LD50 of 75 mg/kg bw. No further information was provided. Based on the limited information, the relevance and validity of the data cannot be assessed.
Reference was made to the following publication:
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 63, 1948.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
