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EC number: 234-522-7
CAS number: 12007-92-0
No skin sensitization studies with Sodium Pentaborates were
available however the data indicate that these borates are not
decahydrate and disodium tetraborate pentahydratewere tested in a
Buehler method skin sensitisation test (Wnorowski, 1994) applied at a
concentration of 95 % (powder moistened with water) during both the
induction and challenge phase of the test. No signs of skin
sensitisation were observed. No evidence of skin sensitisation in humans
exposed occupationally to borates has been reported (Bruze et al., 1995).
A number of these studies were conducted on
an analogue substance. Read-across is justified on the following basis:
In aqueous solutions at physiological and
acidic pH, low concentrations of simple inorganic borates such as boric
acid, disodium tetraborate decahydrate, disodium tetraborate
pentahydrate, boric oxide and disodium octaborate tetrahydrate will
predominantly exist as undissociated boric acid. At
about pH 10 the metaborate anion (B(OH)4-) becomes the main species in
solution (WHO, 1998). This
leads to the conclusion that the main species in the plasma of mammals
and in the environment is un-dissociated boric acid. Since other borates
dissociate to form boric acid in aqueous solutions, they too can be
considered to exist as un-dissociated boric acid under the same
For comparative purposes, exposures to
borates are often expressed in terms of boron (B) equivalents based on
the fraction of boron in the source substance on a molecular weight
basis. Some studies
express dose in terms of B, whereas other studies express the dose in
units of boric acid. Since the systemic effects and some of the local
effects can be traced back to boric acid, results from one substance can
be transferred to also evaluate the another substance on the basis of
boron equivalents. Therefore
data obtained from studies with these borates can be read across in the
human health assessment for each individual substance. Conversion
factors are given in the table under CSR section 5.1.3, which
corresponds to IUCLID section 7.1 (toxicokinetics, metabolism and
distribution endpoint summary).
WHO. Guidelines for drinking-water quality,
Addendum to Volume 1, 1998
Migrated from Short description of key information:
No skin sensitization studies with Sodium Pentaborates were available however the data indicate that these borates are not sensitizers. Skin sensitisation tests on disodium tetraborate decahydrate and disodium tetraborate pentahydrate were performed according to OECD Guideline 406 (Buehler method).
There are no data to suggest that sodium
pentaborate is a respiratory sensitiser.
There are no data to suggest that sodium pentaborate is a respiratory sensitiser.
Sodium pentaborate is not a skin or
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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