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Diss Factsheets
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EC number: 239-784-6 | CAS number: 15687-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- number of replciates lower than recommended in guideline, less soil per replicate
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicological effects on the earthworm Eisenia fetida of 18 common pharmaceuticals in artificial soil
- Author:
- M Rosa Pino, Jonatan Val, Ana M Mainar, Estefanía Zuriaga, Cecilia Español, Elisa Langa
- Year:
- 2 015
- Bibliographic source:
- Science of the Total Environment 518–519 (2015) 225–237
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Version / remarks:
- 1984
- Deviations:
- yes
- Remarks:
- 3 replicates instead of 4; 500 g soil instead of 750 g soil per replicate
- GLP compliance:
- no
Test material
- Reference substance name:
- Ibuprofen
- EC Number:
- 239-784-6
- EC Name:
- Ibuprofen
- Cas Number:
- 15687-27-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-(4-isobutylphenyl)propanoic acid
Constituent 1
- Specific details on test material used for the study:
- Purity: 100%
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: separate assay without earthworms: 0.0100 g/5 g sampled after 14 d
Test substrate
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Remarks:
- standardized OECD soil substrate: industrial fine sand, sphagnum peat, and kaolin clay in a 7:1:2 ratio, water added at amount of 35% of soil dw
- Limit test:
- no
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 20±2 °C
- Moisture:
- 80-85% air humidity
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 1 L polypropylene rectangular jars with lid
- Amount of soil or substrate: 500 g ww
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 3
- No. of replicates per control: 3
OTHER TEST CONDITIONS
- Photoperiod: constant light
- Light intensity: 400-800 lx
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- mortality after 7 and 14 d
TEST CONCENTRATIONS
- Spacing factor for test concentrations:
- Justification for using less concentrations than requested by guideline:
- Range finding study
- Test concentrations: 0–10–200–1000 mg/kg soil dw
- Results used to determine the conditions for the definitive study: not reported - Nominal and measured concentrations:
- nominal: 0, 15, 30, 50, 60, 80, 100, 150 mg/kg dw soil (stability verified in separate assay)
- Reference substance (positive control):
- yes
- Remarks:
- Chloroacetamide
Results and discussion
Effect concentrations
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 64.8 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL: 58.49–71.78 mg/kg soil dw, P < 0.0001, R² of the regression = 0.961
- Details on results:
- - Mortality in negative control at end of exposure period: < 10%
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: 100% mortality at 24 mg/kg soil dw
- Other: - Reported statistics and error estimates:
- log Probit analysis
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.