Registration Dossier
Registration Dossier
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EC number: 239-784-6 | CAS number: 15687-27-1
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ibuprofen
- EC Number:
- 239-784-6
- EC Name:
- Ibuprofen
- Cas Number:
- 15687-27-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-(4-isobutylphenyl)propanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Ibuprofen
- Batch No: 2300; no further details on the test substance characteristics are given.
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2 mg/L
- Based on:
- test mat.
- Details on study design:
- Number of replicates:
- Test substance: 1
- Blank control: 1
- Reference control: 1
- Control DOC changes: 1
- Test substance: 2 mg/L
- Test system: 300 ml BOD-bottles, closed system
- Inoculum: 1 ml/L
- Stock volume: 2000 ml
- Test volume: 300 ml
- pH: 6.3
- Inoculum concentration in the test: 30 mg/L dry weight
- Incubation: at 20 ± 1 °C in the dark
- Measurements: DOC concentration at 0, 5, 15, 21 and 28 days
Reference substance
- Reference substance:
- other: D-glucose
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 20 - 60
- Sampling time:
- 28 d
- Details on results:
- - After 28 days the overall biodegradability for the test substance was 31.1 %. These data suggests that the test substance cannot be considered readily biodegradable since the BOD of the test substance was less than 60 % of its ThOD.
Kinetic of test substance (in %):
= 0 after 5 day(s)
= 0 after 15 day(s)
= 3.9 after 21 day(s)
= 31.3 after 28 day(s)
BOD5 / COD results
- Results with reference substance:
- Kinetic of control substance (in %):
= 49.5 after 5 day(s)
= 42.1 after 28 day(s)
Applicant's summary and conclusion
- Interpretation of results:
- other: moderately/partly biodegradable
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