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EC number: 239-784-6 | CAS number: 15687-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with analytical monitoring
Data source
Reference
- Reference Type:
- publication
- Title:
- Envonrmental fate of pharmaceuticals in water/sediment systems
- Author:
- Löffler D. et al
- Year:
- 2 005
- Bibliographic source:
- Environ. Sci. Technol. 39, 5209 - 5218
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 308 (Aerobic and Anaerobic Transformation in Aquatic Sediment Systems)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ibuprofen
- EC Number:
- 239-784-6
- EC Name:
- Ibuprofen
- Cas Number:
- 15687-27-1
- Molecular formula:
- C13H18O2
- IUPAC Name:
- 2-(4-isobutylphenyl)propanoic acid
- Details on test material:
- - Name of test material (as cited in study report): ibuprofen
- Radiochemical purity (if radiolabelling): > 99%
- Specific activity (if radiolabelling): 8.97 MBq/mg
- Locations of the label (if radiolabelling): carboxyl-14C
Constituent 1
- Radiolabelling:
- yes
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment
- Details on source and properties of surface water:
- - Details on collection:
- Location: Wickerbach creek in Floersheim, Germany; sampling site is located close to the source of the creek
- Selection criteria: absence of sewage treatment plant discharges
- Storage conditions: combined water and sediment were stored at a ratio of (3:1) at 4 °C in the dark
- Storage length: a maximum of 28 d
- pH at time of collection: 8.5
- Electrical conductivity: 515 µS/cm
- Redox potential (mv): 382
- Oxygen concentration (mg/L) initial/final: 7.8
- Hardness (CaCO3): 222 mg/L
- TOC: 4.7 mg/L - Details on source and properties of sediment:
- - Details on collection:
- Location: Wickerbach creek in Floersheim, Germany; sampling site is located close to the source of the creek
- Selection criteria: low but still environmentally relevant organic carbon content; absence of sewage treatment plant discharges
- Sampling depth was restricted to 5 cm, mainly under oxigen conditions
- Storage conditions: combined water and sediment were stored at a ratio of (3:1) at 4 °C in the dark
- Storage length: a maximum of 28 d
- Soil type: loamy sand
- Textural classification
- sand: 77.5%
- silt: 12.6%
- clay): 9.9%
- pH at time of collection: 7.7
- Organic matter (% dw): 2.4
- Redox potential (mv): 269
- Water content: 20 - Duration of test (contact time):
- 100 d
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- test mat. analysis
- Details on study design:
- TEST CONDITIONS
- Test vessel: 500 ml amber glass flasks, the vessels were wrapped with aluminium foil to minimize photochemical reactions
- Volume of water/sediment: 300 ml creek water and 200 g sediment
- CO2 traps: 30 g of granulated soda lime were sealed tightly to the flasks
- Test temperature: 20 ± 2 °C
PRETREATMENT
- Water/sediment systems were equilibrated under test conditions for at least 7 d. During the equilibration and the study period the test system were shaken slowly.
- Test substance was spiked into the water phase at the beginning of the study period.
SAMPLING
- Sampling frequency: after 0, 0.25, 1, 2, 7, 14, 28, 56, 100 d
- Taken samples: entire water, sediment phase, soda lime of each test system
- Sample storage before analysis: at - 20 °C
Results and discussion
Mean total recoveryopen allclose all
- Compartment:
- other: water, material (mass) balance
- % Recovery:
- 90
- Compartment:
- other: sediment, material (mass) balance
- % Recovery:
- 92
% Degradation
- % Degr.:
- 50
- Parameter:
- radiochem. meas.
- Sampling time:
- 6 d
Half-life of parent compound / 50% disappearance time (DT50)
- Compartment:
- entire system
- DT50:
- < 6 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: DT90 < 6 d
- Transformation products:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.