Registration Dossier
Registration Dossier
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EC number: 205-569-0 | CAS number: 142-88-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 142-88-1
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-Multicase model A33, data from GPMT or human experience (ACD Humans)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Sensitization (dermal). Multicase model.
- GLP compliance:
- no
- Type of study:
- not specified
Test material
- Reference substance name:
- Piperazine adipate
- EC Number:
- 205-569-0
- EC Name:
- Piperazine adipate
- Cas Number:
- 142-88-1
- Molecular formula:
- C6H10O4.C4H10N2
- IUPAC Name:
- piperazine adipate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material : piperazine adipate
- Molecular formula : C6H10O4.C4H10N2
- Substance type: Organic
- Physical state: Solid
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: no data
- Vehicle:
- no data
Challenge
- Route:
- other: no data
- Vehicle:
- no data
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- The piperazine adipate does not cause skin sensitisation
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: The piperazine adipate does not cause skin sensitisation.
Any other information on results incl. tables
not sensitizing
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Piperazine adipate gives negative result for skin sensitisation when applied on human skin by using Multicase model A33 from Danish (Q)SAR.
- Executive summary:
Piperazine adipate gives negative result for skin sensitisation when applied on human skin by using Multicase model A33 from Danish (Q)SAR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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