Registration Dossier
Registration Dossier
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EC number: 249-047-0 | CAS number: 28473-19-0
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
DIDS was readily biodegradable in a (closed bottle) test conducted to GLP and in accordance with OECD Guideline 301D (van Ginkel, 2013).
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
DIDS was readily biodegradable in a GLP study conducted according to OECD Guideline 301D. In river water, DIDS at 2 mg/L was degraded by 79% within 28 days, and the 14-day window for the closed bottle test was fulfilled (van Ginkel, 2013).
Relevant read-across data:
DIDA was readily biodegradable in a 28-day ready biodegradability test in activated sludge, with 50.17 mg/L degraded by 76.46% (Anon, 2001). Another unpublished guideline study reported 72% biodegradation of DIDA in 28 days (Anon).
For DOS, 78.2% was degraded after 3 wk of incubation with activated sludge in a reliable guideline study [although reported details were insufficient to conclude on ready biodegradability] (JETOC, 1992). For DEHS, 65% biodegradation was noted following 28 days of incubation with activated sludge, but the compound did not meet the 10-day window criterion for ready biodegradability (Anon, 1994d).
DIDA, DEHS and DOS have all shown significant and rapid biodegradation in relevant studies. This supports the use of these compounds for read-across purposes for DIDS.
References
Anon (1994d). Unpublished confidential business information. [Biodegradation of DEHS.] Testing laboratory: Unknown (cited in ACC, 2010).
Anon (2001). Unpublished confidential business information. [Biodegradation of DIDA.] Testing laboratory: Unknown (cited in ACC, 2010).
Anon [undated]. P Confidential report #21 (cited in CCR).
CCR. Ecological Categorization Results from the Canadian Domestic Substances List. Record onHexanedioic acid, diisodecyl ester. Last accessed 5 April 2013.
JETOC (1992). Japan Chemical Industry Ecology-Toxicology & Information Center. #(entry 17)#.
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