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EC number: 205-466-0
CAS number: 141-18-4
effect of Bis(2-butoxyethyl) adipate on growth of the unicellular algal
species Pseudokirchneriella subcapitata was measured during a 72 hours
exposure period. Results were expressed as % growth inhibition compared
to the control, for biomass and growth inhibition. Test results are
considered valid. The ErC50 is 21.22 mg/l and EbC50 is 8.71 mg/l. The
72h-EC10 for growth rate and biomass are 7.05 and 2.32 mg/l respectively.
The aquatic toxicity was also estimated using the
ECOSAR model v1.10 included in the EpiSuite program of US-EPA.
Bis(2-butoxyethyl) adipate is regarded as an ester. The estimated 96-hr
LC50 value for algae is 2.314 mg/l. The estimated chronic value (ChV) is
1.06 mg/l, the corresponding NOEC is 0.75 mg/l. The acute and chronic
toxicity is overestimated with a factor of 10 by the model.
In ECOSAR, the estimated chronic toxicity is
expressed as the chronic value (ChV). The ChV, is defined as the
geometric mean of the no observed effect concentration (NOEC) and the
lowest observed effect concentration (LOEC). To derive a NOEC, the ChV
can be divided by √2 (REACH Guidance R10, Table R10-1).
The acute and chronic aquatic toxicity of
Bis(2-butoxyethyl) adipate for freshwater fish and Daphnid were also
estimated in ECOSAR v1.10. The estimated 96-hr LC50 values for fish and
Daphnid are 4.5 mg/l and 7.2 mg/l respectively; the ChV values for fish
and Daphnid are estimated to be 0.22 mg/l and 2.95 mg/l; the
corresponding NOEC values are 0.15 mg/l and 2 mg/l.
The EC50 (3h) of bis(2-butoxyethyl) adipate was
determined as 125.2 mg/l (nominal) in an active sludge respiration
inhibition test (OECD test guideline 209).
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