Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
215-607-8
CAS no.:
1333-82-0
Index number:
024-001-00-0
Molecular formula:
CrO3
SMILES:
O=[Cr](=O)=O
InChI:
InChI=1S/Cr.3O
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
20
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, is toxic if swallowed, is toxic in contact with skin, causes severe skin burns and eye damage, may cause genetic defects, may cause cancer, causes damage to organs through prolonged or repeated exposure, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, may cause fire or explosion (strong oxidiser), is suspected of damaging fertility, may cause an allergic skin reaction and may cause allergy or asthma symptoms or breathing difficulties if inhaled.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is fatal in contact with skin, is suspected of damaging fertility or the unborn child and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is fatal if swallowed and causes serious eye damage.

Breakdown of all 593 C&L notifications submitted to ECHA

Skin Corr. 1A H314 Harmonised Classification
Muta. 1B H340 Harmonised Classification
Carc. 1A H350 Harmonised Classification
Repr. 2 H361f Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Ox. Sol. 1 H271 Harmonised Classification
STOT RE 1 H372 Harmonised Classification
Resp. Sens. 1 H334 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
Acute Tox. 2 H330 Harmonised Classification
Acute Tox. 3 H301 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
Acute Tox. 2 H310
Eye Dam. 1 H318
https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L, Candidate list of SVHCs).
  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (26.32% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L, Candidate list of SVHCs).
  • M
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Mutagenic (26.32% of REACH registrations).
  • R
Suspected to be Toxic to Reproduction (Harmonised C&L).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (26.32% of REACH registrations).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Respiratory sensitising (26.32% of REACH registrations).
  • PBT
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Persistent, Bioaccumulative and Toxic (3.13% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 18 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Substance of very high concern requiring authorisation before it is used (Annex XIV of REACH).
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation in materials.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: adsorbents and laboratory chemicals.

This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: laboratory work, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation in materials. Other release to the environment of this substance is likely to occur from: indoor use as reactive substance.

This substance is used in the following products: adsorbents, metal surface treatment products, non-metal-surface treatment products and pH regulators and water treatment products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, mixing in open batch processes, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: formulation in materials and formulation of mixtures.

This substance is used in the following products: metal surface treatment products, pH regulators and water treatment products and non-metal-surface treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals, , fabricated metal products and plastic products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and in the production of articles.

This substance is used in the following activities or processes at workplace: batch processing in synthesis or formulation with opportunity for exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals, laboratory work, closed processes with no likelihood of exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and formulation of mixtures.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: obtain special instructions before use; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: rinse mouth. Do not induce vomiting. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Boeing Distribution, Inc. (d/b/a Aviall), Schillingweg 40 2153PL Nieuw-Vennep Noord-Holland Netherlands
  • Chemservice GmbH - (B1P7), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Clariant Produkte (Deutschland) GmbH, Am Unisys-Park 1 65843 Sulzbach am Taunus Germany
  • CROMITAL S.P.A. in its legal capacity as Only Representative of Türkiye Şişe ve Cam Fabrikaları A.S., Strada Quattro, Pal. A7 - 20090 Assago (MI) Italia 20090 Assago/Milano Italy
  • EGIS Pharmaceuticals PLC, Keresztúri út 30-38 H-1106 Budapest Hungary
  • Elementis Minerals B.V. in its legal capacity as Only Representative of Elementis Chromium Inc., Kajuitweg 8 1041AR Amsterdam Netherlands
  • Global Product Compliance (Europe) AB on the behalf of Vishnu Chemicals, IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden
  • GRACE Catalyst AB, Industrivägen 44432 Stenungsund Sweden
  • GRACE GmbH, In der Hollerhecke 1 67545 Worms Germany
  • Haldor Topsoe A/S, Nymøllevej 50 DK28000 Lyngby Denmark
  • HSO Herbert Schmidt Oberflächentechnik GmbH & Co. KG, Schorberger Straße 18 42699 Solingen Germany
  • INEOS Manufacturing Belgium NV, Scheldelaan 482 2040 Antwerpen Belgium
  • ORLEN Unipetrol RPA s.r.o., Litvinov - Zaluzi 1 43670 Litvinov Czech Republic
  • Prospere Chemical Logistic OÜ as Only Representative of Aktyubinsk Chromium Chemicals Plant, Kazakhstan, Lao 21 74114 Maardu Estonia
  • REGARTIS s.r.o., Rubeska 393/7 19000 Praha Czech Republic
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • SK Nexilis Poland sp. z o.o., ul. L. Tołwińskiego 14 37-450 Stalowa Wola Poland
  • TotalEnergies Polymers Antwerp, Scheldelaan 4 2030 Antwerpen Belgium
  • BASF Nederland B.V., Groningensingel 1 Postbus 1019 6801 MC Arnhem Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Unit 1 Ardee Business Park, Hale Street Co. Louth Ardee Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • Chemservice S.A. (H5P7), 13, Fausermillen 6689 Mertert Luxembourg
  • Clariant Produkte (Deutschland) GmbH - US01, Am Unisys-Park 1 65843 Sulzbach am Taunus Germany
  • Dorf Ketal BV, Weegschaalstraat 3 5632CW Eindhoven Netherlands
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Gentrochema BV, Lage Ham 190 5102 AE Dongen Netherlands
  • Grupa Azoty S.A., ul. Kwiatkowskiego 8 33-101 Tarnow Poland
  • Johnson Matthey PLC, 5th Floor, 25 Farringdon Street EC4A 4AB London United Kingdom
  • REPSOL QUÍMICA, Calle Mendez Alvaro, 44 28045 Madrid Madrid Spain
  • RS Bruce (Metals & Machinery) Ltd, March Street Darnall S9 5DQ Sheffield United Kingdom
  • RusChrome GmbH, Industriestrasse 4 70565 Stuttgart Germany
  • [Confidential], [Confidential]

Substance names and other identifiers

Chromic trioxide
Other
chromium (VI) trioxide
C&L Inventory, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, , Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
Chromium trioxide
EC Inventory, Candidate list, REACH pre-registration
Chromium trioxide
Candidate list, Authorisation list, REACH pre-registration
CHROMIUM TRIOXIDE, ANHYDROUS
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
bezwodnik chromowy (pl)
C&L Inventory
chromo trioksidas (lt)
C&L Inventory
chromtrioxid (da)
C&L Inventory
Chromtrioxid (de)
C&L Inventory
chroomtrioxide (nl)
C&L Inventory
hroma (IV)trioksīds (lv)
C&L Inventory
krom(VI)oksid (no)
C&L Inventory
kromitrioksidi (fi)
C&L Inventory
kromov trioksid (sl)
C&L Inventory
kromov(VI) trioksid (hr)
C&L Inventory
kromtrioksid (no)
C&L Inventory
kromtrioxid (sv)
C&L Inventory
Kroom(VI)trioksiid (et)
C&L Inventory
króm(VI)-trioxid (hu)
C&L Inventory
oxid chromový (cs)
C&L Inventory
oxid chrómový (sk)
C&L Inventory
tlenek chromu(VI) (pl)
C&L Inventory
triossido di cromo (it)
C&L Inventory
trioxide de crom(VI) (ro)
C&L Inventory
trioxyde de chrome (VI) (fr)
C&L Inventory
tritlenek chromu (pl)
C&L Inventory
trióxido de cromo (es)
C&L Inventory
trióxido de crómio (VI) (pt)
C&L Inventory
τριοξείδιο του χρώμιου (VI) (el)
C&L Inventory
хромов (VI) триоксид (bg)
C&L Inventory
Chromium oxide (CrO3)
Other
chomium trioxide
C&L Inventory
Chromic acid
C&L Inventory
Chromic Acid
Registration dossier
Chromium (VI) Oxide
C&L Inventory, Registration dossier
Chromium (VI) Oxide
C&L Inventory, Registration dossier
Chromium (VI) trioxide
C&L Inventory
CHROMIUM TRIOXIDE
C&L Inventory, Registration dossier
Chromium trioxide
C&L Inventory, Registration dossier
Chromium trioxide / Chromium (VI) oxide / Trioxochromium
Registration dossier
Chromium trioxide, Chromium(VI) oxide
Registration dossier
Chromium(VI) trioxide
C&L Inventory, Registration dossier
Chromtrioxid
C&L Inventory
Chromtrioxid
Registration dossier
Trioxochromium
C&L Inventory, Registration dossier, Other
11910080KROMSAV-ANHIDRID IP. 99%
Registration dossier
Acide Chromique
Registration dossier
Aktivkohle, imprägniert, Typ PLWK
Registration dossier
Chromic Acid
Registration dossier
Chromium Catalyst (Activated) CrO3
Registration dossier
Chromium trioxide
Registration dossier
Chromsaure
Registration dossier
Chroomzuur
Registration dossier
CR 0218 P
Registration dossier
CU-0433 T 1/8
Registration dossier
D 3818 S 5 x 8
Registration dossier
D 6600 T 1/8
Registration dossier
Octolyst®
Registration dossier
Specialyst®
Registration dossier
substance only available in mixtures
Registration dossier
024-001-00-0
Index number
C&L Inventory
12324-05-9
CAS number
Other
12324-05-9
Deleted CAS number
Other
12324-08-2
CAS number
Other
12324-08-2
Deleted CAS number
Other
1333-82-0
CAS number
EC Inventory, C&L Inventory, Candidate list, Authorisation list, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, , Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Solid: crystalline (100%) [1]
C Substance type
Inorganic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: crystalline (100%)
Colour
red (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
197 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
197 °C

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 1 study submitted
  • 1 study processed
R Density
2.7 g/cm³ [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
2.7

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
0 - 0 Pa @ 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 1 study submitted
  • 1 study processed
R Water solubility (mass/vol.)
1 690 g/L @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
1 690 g/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Yes (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
-0.61 - 6.488 [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
-0.61

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
23.11

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 1 study processed
R Kd
831 - 5 283 L/kg @ 0.11 - 3.75 % organic carbon [3]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 3.4 µg/L (1)
Intermittent releases (freshwater) 3.4 µg/L (1)
Marine water 3.4 µg/L (1)
Intermittent releases (marine water) 3.4 µg/L (1)
Sewage treatment plant (STP) 210 µg/L (1)
Sediment (freshwater) 150 µg/kg sediment dw (1)
Sediment (marine water) 150 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 35 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 17 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 58.5 mg/L [1]
LC50 (72 h) 58.5 mg/L [1]
LC50 (48 h) 67 mg/L [1]
LC50 (24 h) 96 mg/L [1]
LC50 (12 h) 128 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (40 days) 10 - 100 mg/L [3]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 2.03 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 18 - 350 µg/L [4]
LOEC (21 days) 110 - 640 µg/L [2]
EC50 (24 h) 350 - 930 µg/L [2]
LC50 (21 days) 500 µg/L [1]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (72 h) 380 - 10 000 µg/L [2]
EC50 (48 h) 550 - 13 000 µg/L [2]
EC10 (72 h) 90 - 1 800 µg/L [2]
EC10 (48 h) 150 - 2 100 µg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
130 µg/L
EC10 or NOEC for freshwater algae
10 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (7 days) 320 µg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater plants
100 µg/L

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
IC50 (3 h) 58.7 - 81 mg/L [3]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
110 µg/L
EC10 or NOEC for microorganisms
110 µg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (14 days) 222 - 257 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
222 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (14 days) 350 - 11 000 µg/kg soil dw [6]
EC50 (14 days) 1.8 - 31 mg/kg soil dw [6]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
350 µg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50
5.9 mg/kg soil dw

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
20 mg/kg food

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 7.38 µg/kg bw/day repeated dose toxicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.83 µg/kg bw/day repeated dose toxicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.83 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 8.49 µg/kg bw/day repeated dose toxicity
EYE Exposure
High hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
High bioaccumulation potential
Absorption values
Oral: 10 %
Dermal: 10 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 7 studies submitted
  • 1 study processed
P/RResults
LD50 52 mg/kg bw (rat) [1]
M/CInterpretations of results
Other [1]

Type of Study provided
oral
Studies with data
Key study 1 1
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 6 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 167 - 263 mg/m³ air (rat) [3]

inhalation
Studies with data
Key study 1 1
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 57 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Other [1]

dermal
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 52 mg/kg bw
Inhalation route:
Adverse effect observed LC50 217 mg/m³ air
Dermal route:
Adverse effect observed LD50 57 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irreversible damage)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 2 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 11 studies submitted
  • 5 studies processed
P/RResults
NOAEL (rat): 400 ppm [1]
NOAEL (mouse): 400 ppm [1]
LOAEL (rat): 62.5 mg/L drinking water [1]
LOAEL (mouse): 62.5 mg/L drinking water [2]
LOAEL (mouse): 400 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence 5 5
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 2 studies submitted
  • 2 studies processed
P/RResults
LOAEC (mouse): 1.81 - 3.63 mg/m³ air [2]

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed LOAEL 1.7 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
Adverse effect observed LOAEC 1.81 mg/m³ (subchronic, mouse)
Inhalation route - local effects:
Adverse effect observed LOAEC 1.81 mg/m³ (subchronic, mouse)

Genetic toxicity

Study results
Study data: in vitro
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
Adverse effect observed (positive)
Toxicity - InVivo
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 8 3
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LOAEL 770 µg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence 2 2
Other
Data waiving
no waivers
Study data: developmental
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence 4 3
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 40 mg/kg bw/day (subchronic, mouse)
Effect on developmental toxicity
Oral route:
Adverse effect observed LOAEL 20 mg/kg bw/day (subacute, mouse)

Neurotoxicity

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant