Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-467-2 | CAS number: 60-29-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The long-term toxicity of diethyl ether was evaluated in Daphnia magna. The 21-day NOEC was 100 mg/L under the conditions of the study.
Daphnia magna: LOEC (21-day) = >100 mg/L
Key value for chemical safety assessment
Additional information
One long-term (21-day) toxicity study was performed to assess the toxicity of diethyl ether to Daphnia magna (CRO: LAUS, 2010a). The effect of 21-day exposure on reproduction of Daphnia magna was conducted in a semi-static system according to OECD TG 211, and conducted under GLP. Five nominal concentrations, 10, 18, 32, 56, and 100 mg/L, were tested. The means of measured concentrations lay in the range of 87 – 108% of the nominal concentrations. Therefore, the nominal concentrations were used for the evaluation of the results. Purity of the test substance was 99.93%, pH varied between 7.5 and 8.7, dissolved oxygen concentration was between 8.4 and 11 mg/L and the temperature was 21.6 - 23.2 ± 0.8ºC. The offspring per surviving parent animal were: control 98, 10 mg/L 110, 18 mg/L 112, 32 mg/L 98, 56 mg/L 109, and 100 mg/L 110. Therefore the 21-day NOEC was 100 mg/L and the 21-day LOEC was >100 mg/L under the conditions of the study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
