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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original publication not available. Data based on IUCLID data summary sheet.

Data source

Reference
Reference Type:
publication
Title:
Autooxidative injury with loss of cytochrome P-450 following acute exposure of rats of fasting and ether anesthesia.
Author:
Liu, P.T., Symons, A.M., Parke, D.V.
Year:
1991
Bibliographic source:
Xenobiotica, 1991, 21, 205-215

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Male rats were fasted for 20 hours and exposed to diethyl ether. Cytochrome P450 levels were monitored.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl ether
EC Number:
200-467-2
EC Name:
Diethyl ether
Cas Number:
60-29-7
Molecular formula:
C4H10O
IUPAC Name:
diethyl ether
Details on test material:
No details on test material available.
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
unchanged (no vehicle)
Duration and frequency of treatment / exposure:
6 min
Doses / concentrations
Remarks:
Doses / Concentrations:
ca. 5000 mg/kg bw
No. of animals per sex per dose / concentration:
No data
Control animals:
yes

Results and discussion

Metabolite characterisation studies

Metabolites identified:
not measured
Details on metabolites:
Post exposure there was an increase in exhaled alkanes and indication of lipid peroxidation.

Any other information on results incl. tables

Total cytochrome P-450 levels in the liver and kidney were decreased to 25 -30% of the control animals. Levels were normal 2 hours later.

Cytochrome P-450 I levels were decreased to 35 -44% of the control animals. Levels were 80% 2 hours later.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results