Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original study not available. Based on IUCLID data summary.

Data source

Reference
Reference Type:
publication
Title:
Acute inhalation toxicity of volatile hydrocarbons
Author:
Swann, H.E., Kwon, B.K., Hogan, G.K., Snellings, W.M.
Year:
1974
Bibliographic source:
Am. Ind. Hyg. Assoc. J., 1974, 35, 511-518

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no information available
Principles of method if other than guideline:
No information on the method or guideline used was available.
GLP compliance:
no
Test type:
other: no available information
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl ether
EC Number:
200-467-2
EC Name:
Diethyl ether
Cas Number:
60-29-7
Molecular formula:
C4H10O
IUPAC Name:
diethyl ether
Details on test material:
No information on the test material used is available.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
no information
Concentrations:
No information available.
No. of animals per sex per dose:
No information available. Total of four animals reported.
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LCLo
Effect level:
397 mg/L air (nominal)
Clinical signs:
other: 99.2mg/L displayed slight excitation 198mg/L displayed deep anesthesia 397mg/L irregular respiration and respiratory arrest

Applicant's summary and conclusion