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Diss Factsheets
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EC number: 204-820-1 | CAS number: 127-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Acetone oxime
- EC Number:
- 204-820-1
- EC Name:
- Acetone oxime
- Cas Number:
- 127-06-0
- Molecular formula:
- C3H7NO
- IUPAC Name:
- acetone oxime
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Duration of exposure:
- 24 hours
- Doses:
- 0, 100, 500 and 1000 mg/kg
- No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations: 1,2 and 4 hours after dosing and then daily
- Frequency of weighing: Body weights were obtained prior to dosing and on days 1, 4, 7, 11 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: neurological examinations, haematology, organ weights, histopathology - Statistics:
- Body weights, haematology data, organ weights and organ/body weight rations were analysed statistically.
Results and discussion
- Preliminary study:
- In a preliminary study 1/2 animals died at 1000 mg/kg and 2/2 animals died at 2000 mg/kg
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No animals died in the main study
- Clinical signs:
- At 1000 mg/kg hypoactivity, fecal staining and a darkened iris were seen following dosing and poor food consumption on Day 3. At the lower doses only fecal staining was observed. All animals free of clinical signs from Day 4 of the study. Neurological examination revealed no unusual signs in any animal.
- Body weight:
- Body weights of test animals were comparable to controls.
- Gross pathology:
- No effects noted on organ weights or gross pathology. Microscopic pathology revealed myeloid and erythroid hypercellularity of the femoral bone marrow in all top dose animals and 4/10 mid dose animals.
- Other findings:
- Dose related methaemogloburia was noted on days 1 and/or 5 but not at study termination. Marked differences were noted in most haematology parameters in the top dose animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 for acetone oxime is > 1000 mg/kg
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