Registration Dossier
Registration Dossier
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EC number: 204-820-1 | CAS number: 127-06-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only limited information is available on the website of NTP. However NTP is widely recognised as performing good quality studies. The reliability of the study is based entirely on the fact that it is an NTP study.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Year:
- 2 002
- Bibliographic source:
- US National Toxicology Program (NTP)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A standard US National Toxicology Program (NTP) protocol guideline was followed.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Acetone oxime
- EC Number:
- 204-820-1
- EC Name:
- Acetone oxime
- Cas Number:
- 127-06-0
- Molecular formula:
- C3H7NO
- IUPAC Name:
- acetone oxime
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA97, TA98, TA100 and TA1535
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mixture (Aroclor 1254-induced male Sprague-Dawley rat or Syrian hamster liver)
- Test concentrations with justification for top dose:
- TA 98, 100, TA 1535: 0, 100, 333, 1000, 3333 and 10000 µg/plate.
TA 97: 0, 100, 333, 1000, 2000, 3333, 5000 and 10000 µg/plate. - Vehicle / solvent:
- Water
Controls
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Water
- Positive controls:
- yes
- Positive control substance:
- other: Without metabolic activation: TA97 9-aminoacridine, TA98 2-nitrofluorene, TA100 and TA1535 sodium azide. With metabolic activation: All strains, 2-aminoanthracene
- Details on test system and experimental conditions:
- Pre-incubation assay (37 degC, 20 min)
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA97, TA98, TA100 and TA1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Acetone oxime was not mutagenic in this study
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