Registration Dossier
Registration Dossier
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EC number: 700-475-0 | CAS number: 145783-14-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- Principles of method if other than guideline:
- United States Environmental Protection Agency, Health Effects Test Guidelines, OPPTS 870.2600 (2003): Skin Sensitisation
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine
- EC Number:
- 700-475-0
- Cas Number:
- 145783-14-8
- Molecular formula:
- C7H7Cl2N3O2S
- IUPAC Name:
- 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0.25%, 0.5%, 1% w/v
- No. of animals per dose:
- Number of animals in test group: 4 per dose
Number of animals in negative control group: 4 - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- Hexylcinnamaldehyde was shown to have the capacity to cause skin sensitisation when applied as a 10% w/v preparation in 4:1 acetone in olive oil, confirming the validity of the protocol used for this study.
Number of lymph nodes assayed per concentration: 8
Conc of hexylcinnamaldehyde (% v/w) and DPM:
0 (vehicle only): 5319
2.5: 7365
5: 7502
10: 16679
In vivo (LLNA)
Results
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: DPM/lymph node increased from 665 for the vehicle to 2085 for the highest concentration (1%)
Any other information on results incl. tables
Number of lymph nodes assayed per concentration: 8
0% v/w (vehicle only): DPM = 6929; DPM/lymph node = 665
0.25% v/w: DPM = 59763; DPM/lymph node = 921; test control ratio = 8.63
0.5% v/w: DPM = 131761; DPM/lymph node = 938; test control ratio = 19.02
1% v/w: DPM = 197443; DPM lymph node = 2085; test control ratio = 28.50
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- UL111 is a skin sensitiser under the conditions of the test
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