Registration Dossier
Registration Dossier
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EC number: 700-475-0 | CAS number: 145783-14-8
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine
- EC Number:
- 700-475-0
- Cas Number:
- 145783-14-8
- Molecular formula:
- C7H7Cl2N3O2S
- IUPAC Name:
- 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine
Constituent 1
- Radiolabelling:
- no
Results and discussion
- Preliminary study:
- Preliminary test results based on mean measured concentrations as mg/l of UL111:
Mean % hydrolysis after 5 days at 50 deg C > 98 % at pH 4, pH 7 and pH 9
Hydrolysis was 38.4% at pH 4 and 24.8% at pH7 after 2.5 h
At pH 9 hydrolysis was > 50% after 2.4 h ( no further testing required at this pH)
Applicant's summary and conclusion
- Conclusions:
- The rate of hydrolysis (t1/2) of UL111 at 25 deg C has been estimated to be 26 hours at pH4, 139 hours at pH 7 and less than 24 hours at pH 9
- Executive summary:
Estimated half-life of UL111 at 25 deg C:
pH 4: 26 hours
pH 7: 139 hours
Test concentration:
Nominal concentration of 0.5 mg/l
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