Registration Dossier
Registration Dossier
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EC number: 700-475-0 | CAS number: 145783-14-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Annex V to Council Directive 67/548/EEC on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances, published in the Seventeenth Adaption, Commission Directive 92/69/EEC, OJEC L383A, 121-123, 1992.
United States environmental Protection Agency, Health Effects Test Guidelines, OPPTS(1998) 870.1200 - GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine
- EC Number:
- 700-475-0
- Cas Number:
- 145783-14-8
- Molecular formula:
- C7H7Cl2N3O2S
- IUPAC Name:
- 4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 500, 1000, 1500, 2000 mg/kg
- No. of animals per sex per dose:
- Male: 2000 mg/kg bw. Number of animals: 5
Female: 500, 1000, 1500, 2000 mg/kg bw. Number of animals: 5 in each group - Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 500 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 500 mg/kg bw
- Mortality:
- Male: 2000 mg/kg/bw; Number of deaths; 2. Number of animals: 5
Female: 2000 mg/kg/bw; Number of deaths 5; Number of animals: 5
Female: 1500mg/kg/bw; Number of deaths 5; Number of animals: 5
Female 1000 mg/kg/bw; Number of deaths: 4; Number of animals: 5
Female 500 mg/kg/bw; Number of deaths: 0; Number of animals: 5 - Clinical signs:
- other: Minor clinical signs and signs of skin irritation in surviving animals.
- Gross pathology:
- Following a dose of 2000 mg/kg, macroscopic abnormalties associated with treatment consisted of scabs in the surviving males and one female. The female had an eye discharge which may also have been treatment-related. Following a dose of 1000 mg/kg to females, the surviving animal had scabs and thickened skin. Following a dose of 500 mg/kg to females, all animals had scabs and thickened skin.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose of UL111 is estimated to be approximately 2000 mg/kg to male rats and 803 mg/kg to female rats. Classified Acute toxicity (dermal) Cat 3 based on estimated LD50 for female rats.
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