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Diss Factsheets
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EC number: 806-451-7 | CAS number: 42532-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Heptafluoroisobutyrylnitrile
- Type of composition:
- boundary composition of the substance
- State / form:
- gas
- Reference substance:
- Heptafluoroisobutyrylnitrile
- Name:
- Heptafluoroisobutyrylnitrile
- Type of composition:
- legal entity composition of the substance
- State / form:
- gas
- Reference substance:
- Heptafluoroisobutyrylnitrile
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The parent C4 F-isonitrile is not persistent in aquatic system as it is readily hydrolyzed to heptafluoroisopropylamide. It is not subject to bioaccumulation because of the same hydrolytic instability, and aquatic toxicity cannot be meaningfully tested . The hydrolysis product is very persistent, but is not bioaccumulative based on its log Kow. Acute toxicity studies of the hydrolysis product show no toxicity to fish or aquatic invertebrate up to ca. 100 mg/L, above which testing was not performed. The EC50 was not reached in algae testing, with a NOEC of 10 mg/L. While the most sensitive species had a NOEC well above the toxicity criterion, definitive data are not available for all three trophic levels.
The available mammalian toxicity testing results show the both the parent and the hydrolysis product do not meet the criteria for classification as carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to the CLP regulation.There is no other evidence of chronic toxicity, as identified by the substances NOT meeting criteria for classification: STOT RE1, or STOT RE2 according to the CLP Regulation. The substances are NOT classified as H350, H340, H372, H373, H350i, H360, or H361.
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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