Registration Dossier
Registration Dossier
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EC number: 478-900-1 | CAS number: 6156-18-9
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
2,2 -bis(methylthio)propane was considered to be stable at pH 7 and pH 9. But at pH4 and 1.2, it was found to be hydrolytically unstable. The half-lives at pH4 were respectively 133, 701, 1868 (estimation) and 5373 hours for the temperatures 50, 37, 25 and 15°C. At pH 1.2 and 37°C, a half-life of 1.21h was found.
Key value for chemical safety assessment
Additional information
The hydrolysis at pH 4, 7 and 9 of 2,2 -bis(methylthio)propane was determined in a test performed according to OECD 111 and GLP requirements (Gancet, 2008).The preliminary test showed that the item was unstable at pH 4 and 50°C but stable at pH 7 and 9. Acetone and methyl-mercaptan, the decomposition products of 2,2-Bis(methylthio)propane were detected by the analysis. A definitive test was conducted at pH4 and at 3 temperatures: 15, 37 and 50°C. Hydrolysis of the test item (100 mg/L solution) was conducted in order to obtain an hydrolysis rate between 20 and 70 %. At 50°C, these conditions were observed within 13 days (76% of hydrolysis). For the other temperatures, after 28 days, only 50% of the test item was hydrolysed at 37°C and 7% at 15°C. The results of this test indicated pseudo-first order kinetics. The half-lives at pH4 were respectively 133, 701, 1868 (estimation) and 5373 hours for the temperatures 50, 37, 25 and 15°C. The test was considered to be valid.
In addition, the hydrolysis at pH 1.2 and 37°C of 2,2 -bis(methylthio)propane was determined in a test performed according to OECD 111 and GLP requirements (Gancet, 2009). The preliminary test showed that the item was unstable at pH 1.2 and 37 °C. Acetone and methyl-mercaptan, the decomposition products of the test substance were detected by the analysis. A definitive test was conducted at pH 1.2 and at 37 °C. Hydrolysis of the test item (160 mg/L solution) was conducted in order to obtain an hydrolysis rate between 20 and 70 %. The test substance was unstable at pH 1.2 and 37°C with a half-life of 1.21h. Acetone and methyl mercaptan were identified as decomposition products. The test was considered to be valid.
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