Registration Dossier
Registration Dossier
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EC number: 237-769-9 | CAS number: 13981-86-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental studies of the absorption, distribution, metabolism or elimination of niobium hydride (EC Number 237-769-9; CAS Number 13981-86-7) in mammals are available.
Under physiological conditions the test material cannot be absorbed via the skin or the gastrointestinal tract. After oral administration, the test material will remain in the GI tract until it is excreted via faeces. The test material cannot be metabolised. Under physiological conditions the test material cannot be absorbed and ingested test material will be eliminated via faeces without prior absorption.
As the test material is extremely inert and can only be dissolved under strongly oxidising conditions there is no bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No experimental studies of the absorption, distribution, metabolism or elimination of niobium hydride (EC Number 237-769-9; CAS Number 13981-86-7) in mammals are available. However, the physical chemical properties and the existing toxicity studies on the substance have been used to infer as far as possible, its potential toxicokinetic behaviour.
Niobium hydride is inorganic mono-constituent substance. It is a silver grey solid. Its molecular weight (MW) is 93.91 g/mol. The substance has very low water solubility of <0.000728 mg/L at 20°C. The substance consists of inorganic atoms with no covalent chemical bonds to be broken by the action of water.
Adsorption
The test material is extremely inert and can only be dissolved under strongly oxidising conditions. Under physiological conditions the test material cannot be absorbed via the skin or the gastrointestinal tract. This is supported by the results of the combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in the rats via gavage (OECD 422). With the exception of a borderline change in reproductive toxicity parameter, there were no treatment-related systemic effects observed up to the limit dose. There no signs of dermal absorption in the negative guinea pig maximisation test (OECD 406).
Distribution
After oral administration, the test material will remain in the GI tract until it is excreted via faeces. As the test material is extremely inert and can only be dissolved under strongly oxidising conditions there is no bioaccumulation potential.
Metabolism
The test material is an inorganic substance and it is not expected to be bioavailable. Therefore, the test material is not expected to be metabolised.
Excretion
The test material is extremely inert. Under physiological conditions the test material cannot be absorbed via the oral route and ingested test material will be eliminated via faeces without prior absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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