3-(2,2-dimethyl-3-hydroxypropyl)toluene

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May 06 - May 08 2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

limited details on study performance

Qualifier:

according to guideline

Guideline:

EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))

GLP compliance:

yes

Type of method:

HPLC estimation method

Media:

soil/sewage sludge

Radiolabelling:

no

Test temperature:

Column temperature: 40°C

Details on study design: HPLC method:

EQUIPMENT
- Apparatus: HPLC
- Type, material and dimension of analytical (guard) column: Stationary Phase: LiChrosopher 100 CN, particle diameter: 5µm; length: 250 mm, inner diameter: 4 mm
- Detection system: UV, 220 nm

MOBILE PHASES
- Type: 500 mL acetonitrile : 85 mL buffer solution pH 6* : 415 mL water (*Buffer solution pH6: Riedel de Haen Art. No. 33545)
- Flow rate: 1.2 mL/min, Isocratic
- Injection volume: 10 µL


REFERENCE SUBSTANCES
- Identity: See Table "Any other information on results incl. tables"


EVALUATION
- Calculation of capacity factors k': k' = (tR - t0) / t0

Key result

Sample No.:

#1

Type:

log Koc

Value:

2.67 dimensionless

pH:

6

Temp.:

40 °C

Details on results (HPLC method):

- Retention times of reference substances used for calibration: See "Any other information on results incl. tables"
- Details of fitted regression line (log k' vs. log Koc): see attached graph of regression line
- Graph of regression line attached: yes
- Average retention data for test substance: 3.134

Results:

Calibration substance	Retention time [tR] = min*	Capacity factor k’ *	log k’ *	Log Koc
2-nitrobenzamide	2.306	0.758	-0.120	1.45
N,N-dimethylbenzamide	2.479	0.890	-0.051	1.52
Aniline	2.617	0.995	-0.002	2.07
1,2,3-trichlorobenzene	3.779	1.881	0.274	3.16
Fenthion	4.098	2.124	0.327	3.31
Phenentrene	4.244	2.235	0.349	4.09
Test substance	3.134	1.389	0.143	2.67

* mean value from 3 single values

With sodium nitrate the dead time is 1.312 min

Validity criteria fulfilled:

yes

Conclusions:

In the HPLC Screening study a log Koc of 2.67 was determined for the test substance.

Description of key information

HPLC Screening study (EU C.19): log Koc = 2.67 / Koc = 468

Key value for chemical safety assessment

Koc at 20 °C:

467.7

Additional information

The adsorption of the test substance was determined with a HPLC Screening study according to EU C.19 method. A log Koc of 2.67 was determined in the study.