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EC number: 236-921-1 | CAS number: 13548-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically valid publication in peer reviewed journal that lacks details of test conditions reporting
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- chromic nitrate
- IUPAC Name:
- chromic nitrate
- Reference substance name:
- Chromium trinitrate
- EC Number:
- 236-921-1
- EC Name:
- Chromium trinitrate
- Cas Number:
- 13548-38-4
- Molecular formula:
- Cr.3HNO3
- IUPAC Name:
- chromium trinitrate
- Test material form:
- other: aqueous solution
- Details on test material:
- no data reported in publication
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- age of animals: 8-12 weeks
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- chromium trinitrate was provided as aqueous solution
- Details on exposure:
- 0.5 ml applied, dose 500 Cr(NO3)3*9H2O mg/kg bw and 250 Cr(NO3)3*9H2O mg/kg bw
- Duration of treatment / exposure:
- single application
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
500 mg/kg bw
Basis:
analytical conc.
Cr(NO3)3 * 9H2O
- Remarks:
- Doses / Concentrations:
250 mg/kg bw
Basis:
analytical conc.
Cr(NO3)3 * 9H2O
- No. of animals per sex per dose:
- 5 male animals per dose were used
- Control animals:
- yes
- Positive control(s):
- no positive controls but another substance tested in this array (K2Cr2O7) was found positive.
Examinations
- Tissues and cell types examined:
- Erythrocytes
- Details of tissue and slide preparation:
- The cells of the bone marrow were extracted from the femour and suspended in serum of featal calf. After centrifugation at 1000 rpm during 8 minutes the supernatant was removed and the cells were transferred to a slide and coloured by May-Gruenwald and by Giemsa.
- Evaluation criteria:
- The young erythrocytes which have matured in the last 24 hours can be made visible because of their polychromatophily.
- Statistics:
- Method not reported in publication but statistics was applied.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- other: K2Cr2O7 was found positive in this test array
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Under the conditions of this test chromium trinitrate was found not to affect micronuclei development in vivo. - Executive summary:
In the in-vivo micronucleus test in mice reported in this publication three chromium salts were investigated for their mutagenic potential. Whereas chromium trinitrate was found to be negative, potassium dichromate (chromiumVI) was confirmed to be positive and thus can be seen as positive control in this study. In conclusion, it can be stated that chromium trinitrate was negative in the in-vivo mouse micronucleus test.
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