Registration Dossier
Registration Dossier
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EC number: 236-921-1 | CAS number: 13548-38-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: publication data with peer review
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions.
- Author:
- Vernot EH, MacEwen JD, Haun CC, et al.
- Year:
- 1 977
- Bibliographic source:
- Toxicol Appl Pharmacol 42:417-423
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- chromic nitrate
- IUPAC Name:
- chromic nitrate
- Reference substance name:
- Chromium trinitrate
- EC Number:
- 236-921-1
- EC Name:
- Chromium trinitrate
- Cas Number:
- 13548-38-4
- Molecular formula:
- Cr.3HNO3
- IUPAC Name:
- chromium trinitrate
- Test material form:
- not specified
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rodents were maintained on Purina Formulab Chow 5008.
The animals used in this study were Sprague-Dawley rats, 200-300 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test material was applied in the amount of 0.5 ml as aqueous solutions. Aqueous solutions were made up by diluting pure materials or concentrated solutions to give percentages by weight.
- Control animals:
- other: in this publication more than 50 different componds (inorganic and organic) were assessed of varying toxicity which can be perceived as controls.
- Statistics:
- Where appropriatethe Probit method was used for calculation.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 540 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 270 - < 3 010
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 410 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 900 - < 2 170
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 475 mL/kg bw
- Based on:
- test mat.
- Other findings:
- just summary, no test details
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 (oral, rat):
male: 1540( 1270-3010) mg/kg bw;
females: 1410 (900-2170) mg/kg bw
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