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EC number: 221-254-0 | CAS number: 3047-32-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05/2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- This study has been carried out to OECD guideline 111. Certain test parameters were not met (sterility, temperature variation), however, this is considered to be of little significance to the result. As such, the study is considered Klimisch 2, reliable with restriction.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- yes
- Remarks:
- Certain test parameters were not met (sterility, temperature variation), however, this is considered to be of little significance to the result.
- GLP compliance:
- no
- Remarks:
- This study was conducted in house at Perstorp AB analytical chemistry, R&D
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken for all mixtures after five days
- Buffers:
- Buffer solutions were store bought from Merck. All water used in buffers was of grade 1. Buffer solutions were as follows:
pH 4 buffer: pH 4±0.01 (20oC) (citric acid/sodium hydroxide/hydrogen chloride)
pH 7 buffer: pH 7±0.01 (20oC) (di-sodium hydrogen phosphate/potassium di-hydrogen phosphate)
pH 9 buffer: pH 9±0.01 (20oC) (boric acid/ potassium chloride/ sodium hydrogen) - Details on test conditions:
- See methods below
- Number of replicates:
- No information provided
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- No information provided
- Preliminary study:
- No information provided
- Test performance:
- The repeatability and sensitivity of the method was not validated, but it is considered to fulfil the demands regarding repeatability and sensitivity stated in OECD guideline 111.
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- Not applicable
- % Recovery:
- 98
- Temp.:
- 50 °C
- Duration:
- 5 d
- Key result
- Remarks on result:
- not determinable
- Remarks:
- Hydrolysis of 3-ethyloxetane-3-methanol was found to be less than 10%.
- Details on results:
- Results indicated that hydrolysis was low or non-existant in all test solutions (greatest change -2.5%) the greatest observed loss of test substance was at pH 4. Overall recovery at the end of the test was 98%.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Hydrolysis of 3-ethyloxetane-3-methanol was found to be less than 10% and therefore there is no need for further hydrolysis tests.
- Executive summary:
A study was conducted to assess hydrolysis as a function of pH for 3-ethyoxetane-3-methanol. The pH buffers used were pH 4.0, 7.0 and 9.0. Half of the mixture was stored in a heating cabinet for five days, while the other half was stored at -20oC to act as a reference. After five days mixtures were analysed using HPLC. Results indicated low hydrolytic activity at 50oC, with 98% of the test substance being recovered. As hydrolysis of of 3-ethyloxetane-3-methanol was found to be less than 10% and therefore there is no need for further hydrolysis tests.
Reference
Table 1: Results weigh-in 1
3-ethyloxetane-3-methanol : -20oC(mg/ml) | 3-ethyloxetane-3-methanol: 50oC (mg/ml) | Change (%) | |
pH 4 buffer | 0.351 | 0.346 | -1.42 |
pH 7 buffer | 0.354 | 0.355 | 0.28 |
pH 9 buffer | 0.354 | 0.354 | 0.00 |
Table 2: Results weigh-in 2
3-ethyloxetane-3-methanol : -20oC(mg/ml) | 3-ethyloxetane-3-methanol: 50oC (mg/ml) | Change (%) | |
pH 4 buffer | 0.341 | 0.334 | -2.05 |
pH 7 buffer | 0.342 | 0.341 | -0.29 |
pH 9 buffer | 0.341 | 0.343 | 0.59 |
Table 3: pH at weigh-in 1
pH start | pH 50oCafter 5 days | pH -20oCafter 5 days | |
pH 4 buffer | 4.1 | 4.0 | 4.0 |
pH 7 buffer | 7.1 | 7.1 | 7.1 |
pH 9 buffer | 9.1 | 9.0 | 9.0 |
Table 4: pH at weigh-in 2
pH start | pH 50oC after 5 days | pH -20oC after 5 days | |
pH 4 buffer | 4.1 | 4.0 | 4.0 |
pH 7 buffer | 7.1 | 7.1 | 7.1 |
pH 9 buffer | 9.1 | 9.0 | 9.0 |
Description of key information
Results indicate low hydrolytic activity with 98% of the test substance recovered after 5days at 50oC.
Key value for chemical safety assessment
Additional information
An OECD 111 study was conducted to assess hydrolysis as a function of pH for 3-ethyloxetane-3-methanol (TMPO). The pH buffers used were pH 4.0, 7.0 and 9.0. Half of the mixture was stored in a heating cabinet for five days, while the other half was stored at -20oC to act as a reference. After five days mixtures were analysed using HPLC. Results indicated low hydrolytic activity at 50 oC, with 98% of the test substance being recovered. As hydrolysis of 3-ethyloxetane-3-methanol was found to be less than 10% and therefore there is no need for further hydrolysis tests.
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