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Diss Factsheets
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EC number: 219-834-3 | CAS number: 2549-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- other: Expert assessment
- Adequacy of study:
- weight of evidence
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert assessment based on literature data on the degradation products of VCA
- Justification for type of information:
- An experimental study to determine the toxicity of VCA to reproduction was not considered necessary, nor scientifically justified, since the registered substance is expected to undergo rapid degradation following an oral exposure. Therefore this assessment was based on the degradation products of VCA.
Data source
Reference
- Reference Type:
- other: Expert assessment
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Expert assessment based on literature data on the degradation products of VCA.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Vinyl chloroacetate
- EC Number:
- 219-834-3
- EC Name:
- Vinyl chloroacetate
- Cas Number:
- 2549-51-1
- Molecular formula:
- C4H5ClO2
- IUPAC Name:
- ethenyl 2-chloroacetate
- Test material form:
- liquid
Constituent 1
Results and discussion
Results: P1 (second parental generation)
Effect levels (P1)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 76.67 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- gross pathology
- histopathology: non-neoplastic
Results: F1 generation
Effect levels (F1)
- Remarks on result:
- not measured/tested
Target system / organ toxicity (F1)
- Critical effects observed:
- no
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- No evidences were identified in the literature indicating that the degradation products of VCA are toxic to reproduction. Therefore VCA is not considered as toxic to reproduction.
- Executive summary:
The assessment of the toxicokinetics behaviour of VCA indicates that the substance will undergo rapid hydrolysis following oral exposure. As a result it is considered that the toxicity of the substance to reproduction following oral exposure will be driven by the toxicity to reproduction of its main degradation products, acetaldehyde and chloroacetic acid. Therefore the reproductive toxicity of VCA was assessed based on available information on the degradation products.
It was not possible to identify in the literature dedicated studies investigating the effects of acetaldehyde and chloroacetic acid to fertility. However the effects of these substances to the reproductive organs – and therefore to fertility – following oral exposure were investigated during repeated-dose toxicity studies. Information was identify in the literature regarding the developmental toxicity of acetaldehyde and chloroacetic acid.
No evidences were identified in the literature indicating that the degradation products of VCA are toxic to reproduction. Both substances are fully registered under REACH and were attributed a Harmonised Classification in accordance with Regulation (EC) No.1272/2008. The available information on the substance regarding its toxicity to reproduction did not lead to the substance being classified as toxic to reproduction. No C&L notification was submitted to ECHA including a classification of the substances as toxic to reproduction. Therefore VCA is not considered as toxic to reproduction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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