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Diss Factsheets
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EC number: 231-912-9 | CAS number: 7778-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.3100 (90-Day Oral Toxicity in Rodents)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ammonium perchlorate
- EC Number:
- 232-235-1
- EC Name:
- Ammonium perchlorate
- Cas Number:
- 7790-98-9
- Molecular formula:
- ClHO4.H3N
- IUPAC Name:
- ammonium perchlorate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Details on species / strain selection:
- The test animals were obtained from Charles River Laboratories, Inc., Kingston, NY, USA
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 12 h light/ 12 h darc cycle; 22 +- 2 °C, 50 +- 15% relative humidity, 12 - 15 air changes/h; 2 weeks of acclimation time
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- validated ion chromatography method
- Duration of treatment / exposure:
- 14 and 90 days, respectively
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.01 mg/kg bw/day (nominal)
- Remarks:
- Group 2
- Dose / conc.:
- 0.05 mg/kg bw/day (nominal)
- Remarks:
- Group 3
- Dose / conc.:
- 0.2 mg/kg bw/day (nominal)
- Remarks:
- Group 4
- Dose / conc.:
- 1 mg/kg bw/day (nominal)
- Remarks:
- Group 5
- Dose / conc.:
- 10 mg/kg bw/day (nominal)
- Remarks:
- Group 6
- No. of animals per sex per dose:
- 20 or 30, respectively
- Control animals:
- yes
- Details on study design:
- For each dose group and the control group at least 20 male and 20 female animals were used. At day 14 and day 90, respectively, 10 male and 10 female animals of each group were euthanized and necropsied. In the groups 1, 3, 5 and 6 10 additional animals of each sex were euthanized after a 90-day period of treatment followed by a 30-day period of recovery.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- On all test animals the following examinations and analysis were conducted:
- ophthalmology prior to study initiation
- body weights, weight gain, food and water consumption
- clinical pathology and TSH, T3 and T4 analyses
- estrous cycling or sperm analysis, respectively
- gross necropsy and histopathology
- micronucleus formation - Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, non-treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, non-treatment-related
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- effects observed, non-treatment-related
- Ophthalmological findings:
- no effects observed
- Haematological findings:
- effects observed, non-treatment-related
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- The absolute thyroid weights increased in the group 6 (dose of 10.0 mg/kg/day).
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- The non-neoplastic thyroid histopathological effects are summarizes in the table.
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 1 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- histopathology: non-neoplastic
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 10 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: thyroid effects
Target system / organ toxicity
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 10 mg/kg bw/day (actual dose received)
- System:
- endocrine system
- Organ:
- thyroid gland
- Treatment related:
- yes
- Dose response relationship:
- not specified
- Relevant for humans:
- yes
Any other information on results incl. tables
The non-neoplastic thyroid histopathological effects are summarizes in the table.
total incidences | Group 1 (0 mg/kg/day) | Group 2 (0.01 mg/kg/day) | Group 3 (0.05 mg/kg/day) | Group 4 (0.2 mg/kg/day) | Group 5 (1.0 mg/kg/day) | Group 6 (10.0 mg/kg/day) |
14-day interval, males | 1/8 | 0/10 | 1/10 | 0/10 | 0/10 | 10/10 |
14 -day interval, females | 0/10 | 0/10 | 0/10 | 0/10 | 0/10 | 7/10 |
90-day interval, males | 2/10 | 0/10 | 0/10 | 0/10 | 1/10 | 8/10 |
90-day interval, females | 0/10 | 0/10 | 0/10 | 0/10 | 0/10 | 9/10 |
Applicant's summary and conclusion
- Conclusions:
- The NOAEL for ammonium perchlorate was determined to be 1.00 mg /kg bw/d.
The NOAEL for potassium perchlorate is 1.18 mg /kg bw/d.
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